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Jeopardy!

Jeopardy!. Immunology Edition! By: Brian Jackson, MS I. Instructions. Choose the category and dollar amount. The answer will appear on your screen. Once you’ve answered, click anywhere for the correct question. IMPORTANT: Click on the correct question to return to the board!

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Jeopardy!

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  1. Jeopardy! Immunology Edition! By: Brian Jackson, MS I

  2. Instructions • Choose the category and dollar amount. The answer will appear on your screen. • Once you’ve answered, click anywhere for the correct question. • IMPORTANT: Click on the correct question to return to the board! • When you’re done with a section, click on the link at the bottom of the board to advance.

  3. Click Here to advance to Double Jeopardy

  4. Click here to return to the board.

  5. Click to advance to Final Jeopardy

  6. Click here to return to the board.

  7. Final Jeopardy! • Category: Immunology People • Make your wagers now. After you have made your wager, click anywhere to continue to the Final Jeopardy answer, which you will need to write down on your own paper.

  8. Final Jeopardy! • Category: Immunology People • He gave his name to the attenuated live polio vaccine administered outside of the United States. • (slide will advance automatically after 30 seconds)

  9. Final Jeopardy • The correct question is... • (click anywhere to see) • Who is Albert Sabin?

  10. Thanks for playing! • Let me know if you had problems with the program or if any of the questions/answers are wrong! Comments are always appreciated as well! • E-mail: brianjac@gwu.edu • End Game By Clicking Here

  11. $200 – “IL” Wind • This cytokine is secreted by APCs and promotes secretion of interferon gamma. • What is IL-12?

  12. $400 – “IL” Wind • This cytokine promotes immunoglobulin switching to IgE. • What is IL-4?

  13. $600 – “IL” Wind • This cytokine promotes eosinophil growth. • What is IL-5?

  14. $800 – “IL” Wind • These two cytokines are responsible for the acute phase inflammation response. • What are IL-1 and IL-6?

  15. $1000 – “IL” Wind • This molecule is expressed on stromal cells in the thymus and is required for proper T-Cell development. • What is IL-7?

  16. $200 – Be Sensitive • This type of hypersensitivity reaction is mediated by histamine, serotonin, heparin, and chemotactic factors. • What is a Type I reaction?

  17. $400 – Be Sensitive • The hypersensitivity reaction most associated with a delay of 24 to 72 hours. • What is a Type IV reaction?

  18. $600 – Be Sensitive • Serum sickness is an example of this type of hypersensitivity? • What is a Type III hypersensitivity?

  19. $800 – Be Sensitive • This is a Type II reaction by a fetus to maternal Rh antibody. • What is erythroblastosis fetalis?

  20. $1000 – Be Sensitive • This condition is a common sign of a Type I hypersensitivity, and is found when cells bind to ADCC via F-c receptors for IgG and IgE. • What is eosinophilia?

  21. $200 – Sharing is Caring • A positive crossmatch test indicates that this type of reaction to an allograft is likely. • What is a hyperacute reaction?

  22. $400 – Sharing is Caring • An acute rejection requires these two things. • What are allospecific T-cells and a context of disease (or inflammation)?

  23. $600 – Sharing is Caring • This is the most common cause of death among transplant patients in the first year after transplant. • What are cardiovascular problems?

  24. $800 – Sharing is Caring • Cyclosporine is this type of immunosuppressant. • What is a calcineurin inhibitor?

  25. $1000 – Sharing is Caring • This organ was the first successful allograft in humans. • What is the kidney?

  26. $200 – Less Than Ideal • The “boy in the bubble” had this type of immune deficiency. • What is SCID (Severe Combined Immune Deficiency)?

  27. $400 – Less Than Ideal • This is an isotype switch defect with an increased amount of IgM and a decreased amount of other Ig’s. • What is X-Linked Hyper-IgM Syndrome?

  28. $600 – Less Than Ideal • Most immunodeficiency diseases are of this general type. • What are antibody deficencies?

  29. $800 – Less Than Ideal • Examples of deects in this system include decreased microbicidal activities in phagocytes, defects in NK cells, and complement deficiencies. • What is the innate immune system?

  30. $1000 – Less Than Ideal • This autosomal recessive disorder involves CD18 and results in chronic leukocytosis, defective wound healing, and recurrent bacterial and fungal infections. • What is Leukocyte Adhesion Deficiency Type 1?

  31. $200 – Ouch! That Hurt! • Alum is the only approves one of these in humans. • What is an adjuvant?

  32. $400 – Ouch! That Hurt! • MMR and Varicella zoster are both vaccines of this type. • What are live, attenuated vaccines?

  33. $600 – Ouch! That Hurt! • The IgA antibodies in breastmilk provide this type of immunity to an infant. • What is passive immunity?

  34. $800 – Ouch! That Hurt! • The Hepatitis B vaccine was the first to use this technology. • What is recombinant DNA technology?

  35. $1000 – Ouch! That Hurt! • The WHO hopes that this disease will be eliminated by vaccination by the year 2010. • What is polio?

  36. $200 – Feeling Sick • This type of pathogen can replicate using RNA or DNA. • What is a virus?

  37. $400 – Feeling Sick • An example of this type of pathogen is Candida albicans. • What is a fungus?

  38. $600 – Feeling Sick • This bacteria causes toxic shock and skin abscesses and evades the immune system by means of a superantigen. • What is staphylococcus?

  39. $800 – Feeling Sick • African Sleeping Sickness is caused by this protozoan. • What is Trypanosome?

  40. $1000 – Feeling Sick • These two main antigens in influenza determine the classification of the virus. • What are hemagglutinin and neuraminidase?

  41. $400 – Barely Tolerated • The name for sites where antigens are kept separate from most lymphocytes to prevent an immune response. • What are immunologically privileged sites?

  42. $800 – Barely Tolerated • This is the most important genetic factor involved in autoimmune disease pathogenesis. • What is MHC type?

  43. $1200 – Barely Tolerated • Autoimmune Polyendocrinopathy Candidiasis Ectodermal Dystrophy involves a genetic defect in this gene. • What is the AIRE gene?

  44. $1600 – Barely Tolerated • This molecule negatively regulates T cell activation, and mice without this molecule have a lethal autoimmune lymphoproliferative syndrome. • What is CTLA-4?

  45. $2000 – Barely Tolerated • Lymphocytes that persistently receive a primary stimulatory signal without a co-stimulatory signal are likely to end up in this inactive state. • What is anergy?

  46. $400 – Innate Talents • These two complement molecules are chemoattractants for additional lymphocytic infiltration. • What are C3a and C5a?

  47. $800 – Innate Talents • CD8+CD4- T-cells are associated with this type of MHC Complex. • What is MHC Class 1?

  48. $1200 – Innate Talents • Toll like receptors are an example of receptors that bind these molecules. • What are PAMPs • (pathogen associated molecular patterns)?

  49. $1600 – Innate Talents • C3b is this type of molecule that enhances phagocytosis. • What is an opsin?

  50. $2000 – Innate Talents • This enzyme is primarily responsible for the oxidative burst in macrophages. • What is NADPH oxidase?

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