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Jeopardy!. Immunology Edition! By: Brian Jackson, MS I. Instructions. Choose the category and dollar amount. The answer will appear on your screen. Once you’ve answered, click anywhere for the correct question. IMPORTANT: Click on the correct question to return to the board!

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jeopardy

Jeopardy!

Immunology Edition!

By: Brian Jackson, MS I

instructions
Instructions
  • Choose the category and dollar amount. The answer will appear on your screen.
  • Once you’ve answered, click anywhere for the correct question.
  • IMPORTANT: Click on the correct question to return to the board!
  • When you’re done with a section, click on the link at the bottom of the board to advance.
final jeopardy
Final Jeopardy!
  • Category: Immunology People
  • Make your wagers now. After you have made your wager, click anywhere to continue to the Final Jeopardy answer, which you will need to write down on your own paper.
final jeopardy1
Final Jeopardy!
  • Category: Immunology People
  • He gave his name to the attenuated live polio vaccine administered outside of the United States.
  • (slide will advance automatically after 30 seconds)
final jeopardy2
Final Jeopardy
  • The correct question is...
  • (click anywhere to see)
  • Who is Albert Sabin?
slide10
Thanks for playing!
  • Let me know if you had problems with the program or if any of the questions/answers are wrong! Comments are always appreciated as well!
  • E-mail: brianjac@gwu.edu
  • End Game By Clicking Here
200 il wind
$200 – “IL” Wind
  • This cytokine is secreted by APCs and promotes secretion of interferon gamma.
  • What is IL-12?
400 il wind
$400 – “IL” Wind
  • This cytokine promotes immunoglobulin switching to IgE.
  • What is IL-4?
600 il wind
$600 – “IL” Wind
  • This cytokine promotes eosinophil growth.
  • What is IL-5?
800 il wind
$800 – “IL” Wind
  • These two cytokines are responsible for the acute phase inflammation response.
  • What are IL-1 and IL-6?
1000 il wind
$1000 – “IL” Wind
  • This molecule is expressed on stromal cells in the thymus and is required for proper T-Cell development.
  • What is IL-7?
200 be sensitive
$200 – Be Sensitive
  • This type of hypersensitivity reaction is mediated by histamine, serotonin, heparin, and chemotactic factors.
  • What is a Type I reaction?
400 be sensitive
$400 – Be Sensitive
  • The hypersensitivity reaction most associated with a delay of 24 to 72 hours.
  • What is a Type IV reaction?
600 be sensitive
$600 – Be Sensitive
  • Serum sickness is an example of this type of hypersensitivity?
  • What is a Type III hypersensitivity?
800 be sensitive
$800 – Be Sensitive
  • This is a Type II reaction by a fetus to maternal Rh antibody.
  • What is erythroblastosis fetalis?
1000 be sensitive
$1000 – Be Sensitive
  • This condition is a common sign of a Type I hypersensitivity, and is found when cells bind to ADCC via F-c receptors for IgG and IgE.
  • What is eosinophilia?
200 sharing is caring
$200 – Sharing is Caring
  • A positive crossmatch test indicates that this type of reaction to an allograft is likely.
  • What is a hyperacute reaction?
400 sharing is caring
$400 – Sharing is Caring
  • An acute rejection requires these two things.
  • What are allospecific T-cells and a context of disease (or inflammation)?
600 sharing is caring
$600 – Sharing is Caring
  • This is the most common cause of death among transplant patients in the first year after transplant.
  • What are cardiovascular problems?
800 sharing is caring
$800 – Sharing is Caring
  • Cyclosporine is this type of immunosuppressant.
  • What is a calcineurin inhibitor?
1000 sharing is caring
$1000 – Sharing is Caring
  • This organ was the first successful allograft in humans.
  • What is the kidney?
200 less than ideal
$200 – Less Than Ideal
  • The “boy in the bubble” had this type of immune deficiency.
  • What is SCID (Severe Combined Immune Deficiency)?
400 less than ideal
$400 – Less Than Ideal
  • This is an isotype switch defect with an increased amount of IgM and a decreased amount of other Ig’s.
  • What is X-Linked Hyper-IgM Syndrome?
600 less than ideal
$600 – Less Than Ideal
  • Most immunodeficiency diseases are of this general type.
  • What are antibody deficencies?
800 less than ideal
$800 – Less Than Ideal
  • Examples of deects in this system include decreased microbicidal activities in phagocytes, defects in NK cells, and complement deficiencies.
  • What is the innate immune system?
1000 less than ideal
$1000 – Less Than Ideal
  • This autosomal recessive disorder involves CD18 and results in chronic leukocytosis, defective wound healing, and recurrent bacterial and fungal infections.
  • What is Leukocyte Adhesion Deficiency Type 1?
200 ouch that hurt
$200 – Ouch! That Hurt!
  • Alum is the only approves one of these in humans.
  • What is an adjuvant?
400 ouch that hurt
$400 – Ouch! That Hurt!
  • MMR and Varicella zoster are both vaccines of this type.
  • What are live, attenuated vaccines?
600 ouch that hurt
$600 – Ouch! That Hurt!
  • The IgA antibodies in breastmilk provide this type of immunity to an infant.
  • What is passive immunity?
800 ouch that hurt
$800 – Ouch! That Hurt!
  • The Hepatitis B vaccine was the first to use this technology.
  • What is recombinant DNA technology?
1000 ouch that hurt
$1000 – Ouch! That Hurt!
  • The WHO hopes that this disease will be eliminated by vaccination by the year 2010.
  • What is polio?
200 feeling sick
$200 – Feeling Sick
  • This type of pathogen can replicate using RNA or DNA.
  • What is a virus?
400 feeling sick
$400 – Feeling Sick
  • An example of this type of pathogen is Candida albicans.
  • What is a fungus?
600 feeling sick
$600 – Feeling Sick
  • This bacteria causes toxic shock and skin abscesses and evades the immune system by means of a superantigen.
  • What is staphylococcus?
800 feeling sick
$800 – Feeling Sick
  • African Sleeping Sickness is caused by this protozoan.
  • What is Trypanosome?
1000 feeling sick
$1000 – Feeling Sick
  • These two main antigens in influenza determine the classification of the virus.
  • What are hemagglutinin and neuraminidase?
400 barely tolerated
$400 – Barely Tolerated
  • The name for sites where antigens are kept separate from most lymphocytes to prevent an immune response.
  • What are immunologically privileged sites?
800 barely tolerated
$800 – Barely Tolerated
  • This is the most important genetic factor involved in autoimmune disease pathogenesis.
  • What is MHC type?
1200 barely tolerated
$1200 – Barely Tolerated
  • Autoimmune Polyendocrinopathy Candidiasis Ectodermal Dystrophy involves a genetic defect in this gene.
  • What is the AIRE gene?
1600 barely tolerated
$1600 – Barely Tolerated
  • This molecule negatively regulates T cell activation, and mice without this molecule have a lethal autoimmune lymphoproliferative syndrome.
  • What is CTLA-4?
2000 barely tolerated
$2000 – Barely Tolerated
  • Lymphocytes that persistently receive a primary stimulatory signal without a co-stimulatory signal are likely to end up in this inactive state.
  • What is anergy?
400 innate talents
$400 – Innate Talents
  • These two complement molecules are chemoattractants for additional lymphocytic infiltration.
  • What are C3a and C5a?
800 innate talents
$800 – Innate Talents
  • CD8+CD4- T-cells are associated with this type of MHC Complex.
  • What is MHC Class 1?
1200 innate talents
$1200 – Innate Talents
  • Toll like receptors are an example of receptors that bind these molecules.
  • What are PAMPs
  • (pathogen associated molecular patterns)?
1600 innate talents
$1600 – Innate Talents
  • C3b is this type of molecule that enhances phagocytosis.
  • What is an opsin?
2000 innate talents
$2000 – Innate Talents
  • This enzyme is primarily responsible for the oxidative burst in macrophages.
  • What is NADPH oxidase?
400 organs of the body
$400 – Organs of the Body
  • This immune system organ is made up of red pulp and white pulp.
  • What is the spleen?
800 organs of the body
$800 – Organs of the Body
  • The two immune organs designated as “primary.”
  • What are the bone marrow and the thymus?
1200 organs of the body
$1200 – Organs of the Body
  • The T-Cell zone within the spleen that surrounds certain blood vessels.
  • What is the periarteriole lymphoid sheath?
1600 organs of the body
$1600 – Organs of the Body
  • This lymphatic vessel empties into the left subclavian vein or the left jugular vein.
  • What is the thoracic duct?
2000 organs of the body
$2000 – Organs of the Body
  • Areas of enhanced lymphocytic activity in the submucosa of the small intestine are called these.
  • What are Peyer’s patches?
400 develop yourself
$400 – Develop Yourself
  • B cell development is completed in this organ.
  • What is the bone marrow?
800 develop yourself
$800 – Develop Yourself
  • Most T-cell receptors are made up of these two chains.
  • What are alpha and beta?
1200 develop yourself
$1200 – Develop Yourself
  • Receptor editing (additional chain rearrangements) occurs in this type of cell only.
  • What are B cells?
1600 develop yourself
$1600 – Develop Yourself
  • Immediately prior to lineage commitment as CD4 or CD8 cells, T-cells are called this.
  • What are double positive T cells?
2000 develop yourself
$2000 – Develop Yourself
  • The principle that there is only one type of receptor per one lymphocyte is called this.
  • What is allelic exclusion?
400 signal received
$400 – Signal Received
  • Found in pentamer form, this is the first type of immungloublin produced by B cells.
  • What is IgM?
800 signal received
$800 – Signal Received
  • Cytotoxic T-cells use this three-lettered receptor and its ligand to kill infected cells.
  • What is fas?
1200 signal received
$1200 – Signal Received
  • The process of changing from producing IgM to producing other immunoglobulins is called this.
  • What is isotype switching?
1600 signal received
$1600 – Signal Received
  • Interferon gamma is most associated with this type of T cell.
  • What is a Th1 cell?
2000 signal received
$2000 – Signal Received
  • Cells with these two CD numbers regulate T cells by secreting IL-10 and TGF-beta.
  • What are CD4/CD25?
400 diagnosis immunity
$400 – Diagnosis: Immunity
  • This ABO blood type is the universal donor?
  • What is O?
800 diagnosis immunity
$800 – Diagnosis: Immunity
  • ThoGAM is this type of antibody against Rh antigen.
  • What is IgG?
1200 diagnosis immunity
$1200 – Diagnosis: Immunity
  • A direct Coombs test detects antibodies bound to this type of cell.
  • What is a red blood cell/erythrocyte?
1600 diagnosis immunity
$1600 – Diagnosis: Immunity
  • A type IV delayed hypersensitivity reaction is used in a skin test for this disease.
  • What is Tuberculosis?
2000 diagnosis immunity
$2000 – Diagnosis: Immunity
  • A vaccine for HPV may help to prevent this type of cancer.
  • What is cervical cancer?