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Heart comorbidity correlates with lung toxicity after (chemo)radiotherapy. Georgi Nalbantov, 2013. Results: cardiac comorbidity and dyspnea ≥ 2 are correlated. 2 5 9 patients, training dataset Patients from azM Maastricht and Atrium Heerlen (The Netherlands).

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heart comorbidity correlates with lung toxicity after chemo radiotherapy
Heart comorbidity correlates with lung toxicity after (chemo)radiotherapy

Georgi Nalbantov, 2013

results cardiac comorbidity and dyspnea 2 are correlated
Results: cardiac comorbidity and dyspnea ≥ 2 are correlated

259 patients, training dataset

Patients from azM Maastricht and Atrium Heerlen (The Netherlands)

WITH cardiac comorbidity:

77 patients (30% of all)

43

140

WITH max dyspnea >=2:

76 patients (29% of all)

% patients per group

Odds ratio= (34/43) / (42/140) = 2.6

P-value = 0.0006

34

42

With cardiac

comorbidity

No cardiac comorbidity

Nalbantov et al, 2013 (Radiotherapy and Oncology)

results cardiac comorbidity and dyspnea 2 are correlated1
Results: cardiac comorbidity and dyspnea ≥ 2 are correlated

185 patients, validation set

107 patients from UZ Gent (Belgium) and 78 from Univ. Medical Center Nijmegen (Netherlands)

WITH cardiac comorbidity:

34 patients (18% of all)

17

104

WITH max dyspnea >=2:

76 patients (34% of all)

% patients per group

Odds ratio= (17/17) / (47/104) = 2.2

P-value = 0.037

17

47

With cardiac

comorbidity

No cardiac comorbidity

Nalbantov et al, 2013 (Radiotherapy and Oncology)

results multi variate analysis
Results: Multivariate analysis

Variable selection method: the Wrapper approach

Output

Dyspnea grade >=2 between 1-6 months after treatment

Training set (n=259):

AUC = 0.722

Validation set (n=107):

AUC = 0.727

MLD-only model (n=366):

AUC = 0.502

Nalbantov et al, 2013 (Radiotherapy and Oncology)

results no significant correlation found between heart irradiation and dyspnea 2
Results: no significant correlation found between heart irradiation and dyspnea ≥ 2

no CC

with CC

n=259 patients, training dataset

p-value =

0.708

Max dyspnea < 2

Max dyspnea ≥ 2

Max dyspnea < 2

Max dyspnea ≥ 2

Box plot

CC = cardiac comorbidity

Nalbantov et al, 2013 (Radiotherapy and Oncology)