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Insights into Gene Regulation: Key Transcription Factors and Their Interactions

This study delves into the complex interactions among various transcription factors, such as p53, AP-2, E2F, NF-κB, and STAT, emphasizing their roles in gene regulation. We examine their binding sites and enhancer activity across a range of gene loci, including clinically relevant pathways. By integrating data from multiple sources, we provide a comprehensive overview of how these factors work together, influencing transcriptional outcomes and potentially leading to insights in cancer biology and therapeutic targets.

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Insights into Gene Regulation: Key Transcription Factors and Their Interactions

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  1. H4TF-2 GCF GCF ETF ZF5 TEF1 p53 STAT(1and 5A) AP2ALPHA AP-2 AML1 SP-1 E2F PAX2 IRF1 CETS168 AHRHIF GCF GCF STAT (5A and 6) GCF E2F GCF CAP AP-2 SP-1 AHRHIF TEL2 IRF EGR-1 CDXA ETS CAP NF-κB TCF-1 USF2 SP-1 p53 GEN_INI1-2-3 E2F AML1 PEA3 AP-1 AP-2 NF-κB PU.1 ECR2 ECR1 -750 -500 -250 +1 -1000

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