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Aging Cognition Evaluation. A Unique Opportunity in understanding age related disorders. Improve understanding of the biology of memory disorder with concurrently collected serial: Cognitive data Biological samples Clinical events Potential applications across other pathologies

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Presentation Transcript
slide1

Aging Cognition Evaluation

A Unique Opportunity in understanding age related disorders

slide2

Improve understanding of the biology of memory disorder with concurrently collected serial:

    • Cognitive data
    • Biological samples
    • Clinical events
  • Potential applications across other pathologies
  • Discover predictive biomarkers
slide3

Objectives

  • Establish robust baseline cognition score
  • Identify meaningful changes in cognition
  • Follow cognition deficits and rate of change
  • Correlate changes in cognition score with changes in biology
  • Identify well characterized patients for further evaluation
slide4

Outputs

BIOLOGICAL

  • Genomic DNA
  • RNA from PAXGene
  • PBMCs ~4ml
  • Serum 0.5ml
  • Plasma 0.5ml
  • Urine 5ml
  • CSF 0.5ml (subpopulation)

DEMOGRAPHIC

  • Family History
  • Current Meds
  • Ethnic History
  • Education
  • Smoking
  • Alcohol
  • Clinical events

PSYCHOMETRIC

  • Semantic memory
  • Working memory
  • Executive function
  • Concentration
  • Response speed
  • MMSE
slide5
6-monthly serial follow-up of up to 5000 healthy subjects >60 y/o.
  • Collection of biological fluid samples including CSF (subpopulation) with simultaneous clinical and cognition evaluations using a CDR cognition battery at each 6 monthly visit.

Protocol

slide6

The ACE Solution: identify MCI using…

…evidence of progressive cognitive decline

slide8

Protocol design

Age 60-75

Able to present for a blood

draw every 6 months

Generally healthy

Cognitively normal

Cognition diminished

Cognition diminished

6 months

6 months

Cognition normal

Cognition Battery

Con Meds

Con Diagnoses

Blood Draw

Spinal Tap (subpopulation)

6 months

V.2

SCR.

V.1

6 months

Controls

6 months

Consent

CDR Cognition Battery training

Con Meds

Con Diagnoses

Family history

ECG

Other tests

Cognition Battery

Con Meds

Con Diagnoses

Blood Draw

Spinal Tap (subpopulation)

slide9

Protocol design Contd:

* Subpopulation

** Training