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Multipurpose Prevention Technologies What are they & why do we need them?

Multipurpose Prevention Technologies What are they & why do we need them?. [Presenter name, degree, affiliation] [Event title]. [Date]. Multipurpose Prevention Technologies for Reproductive Health. What do women want and need?. Every year. 80 million unintended pregnancies

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Multipurpose Prevention Technologies What are they & why do we need them?

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  1. Multipurpose Prevention TechnologiesWhat are they & why do we need them? [Presenter name, degree, affiliation] [Event title] [Date]

  2. Multipurpose Prevention Technologies for Reproductive Health What do women want and need?

  3. Every year. . . • 80 million unintended pregnancies • 358,000 women die from pregnancy- related complications • 2.5 million people infected with HIV • 340 million new gonorrhea, syphilis, trichomonas infections • 250,000 deaths from cervical cancer • 16 % (15-49) have genital herpes (HSV-2)

  4. products that… Imagine • Prevent pregnancy, HIV/AIDS & STIs at the same time • Ensure women’s privacy and safety • Are affordable & easily available • Are designed by women for their specific needs & preferences

  5. Multipurpose Prevention Technologies

  6. The Challenge

  7. 50 years of contraceptive advances Sheldon Segal First long term drug delivery device Norplant

  8. ;Female-controlled MPTs Female Condom SILCS Diaphragm Women’s Condom

  9. Currently available MPTs Female Condom Male Condom

  10. Emerging MPTs Drug combinations Multipurpose vaccines Drug/device combinations Bacterial therapeutics Nanoparticals

  11. Potential Delivery Mechanisms for MPTs • Devices • SILCS Diaphragm • Women’s Condom • Vaginal Rings • Drug release rates differ by ring type • Matrix rings vs. Reservoir rings • Release rates differ in-vitro from in-vivo • Vaginal Tablet • Combining different class ART • Vaginal Film • Nontoxic to cells and flora, fast dissolution

  12. Multipurpose Vaccines: the future • Today: Single purpose vaccines (HPV & HBV) are commercially available • Next 2 decades: Dual-purpose vaccines that prevent transmission of HSV, HIV, Gonorrhea, Chlamydia, Trichomonas or other STIs • Contraceptive vaccines not likely

  13. Collaboration, advocacy, & research to advance MPTs

  14. Initiative on MPTs: Partner Organizations

  15. MPTs in the Pipeline Mapping Matrix: www.cami-health.org

  16. CAMI Activities • MPT Think Tank (May 2011) • Target Product Profile working groups (May – Oct 2011) • ARHP Conference (September 2011) • APHA Conference (October 2011) • International MPT Symposium, DC (November 2011) • International MPT Symposium, London (January 2012) • Microbicides 2012 Conference, Sydney (April 2012) • NEXT STEPS

  17. Future directions and priorities • Support and coordinate novel approaches for multi-disciplinary collaboration • Facilitate funding for research & development • Expand global and US support • Refine priority Product Profiles • Assist with clarifying the regulatory pathways

  18. Questions? • www.cami-health.org • www.arhp.org • www.phi.org

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