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Which One ?. Fast. Economic. Convenience. Efficient. 如何 查阅 、 筛选 和 获取 高质量 文献. Library of CAMS/PUMC 李 越. Apr. 18, 2012. What is the Literature?. How to find ?. How to evaluate ?. How to read ?. How to analysis ?. How to manage ?. About the Literature. Come from Study (evidence).

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slide1
Which One?

Fast

Economic

Convenience

Efficient

slide2
如何查阅、筛选和获取高质量文献

Library of CAMS/PUMC

李 越

Apr. 18, 2012

slide3
What is the Literature?

How to find ?

How to evaluate ?

How to read ?

How to analysis ?

How to manage ?

slide5
Come fromStudy(evidence)
  • Original
  • Randomized Controlled Trials(RCT)
  • Cohort Study
  • Retrospective Study(case control)
  • ……
slide6
Come fromStudy(evidence)
  • 2nd
  • Systematic Reviews
  • Meta Analysis
  • Clinical Practice Guideline( CPG)
  • ……
slide7
Come fromStudy(evidence)
  • 3rd
  • News
  • Meeting
  • Bibliography
  • Database
  • ……
slide11
NCBI(National Center for Biotechnology Information)
  • General Introduction
    • Established on 1988, as a division of the National Library of Medicine (NLM) at the National Institutes of Health (NIH).
    • Http://www.ncbi.nlm.nih.gov
ncbi national center for biotechnology information
NCBI(National Center for Biotechnology Information)

General Introduction

Conducts research on fundamental biomedical problems at the molecular level using mathematical and computational methods

Maintains collaborations with several NIH institutes, academia, industry, and other governmental agencies

Fosters scientific communication by sponsoring meetings, workshops, and lecture series

Supports training on basic and applied research in computational biology for postdoctoral fellows through the NIH Intramural Research Program

ncbi national center for biotechnology information1
NCBI(National Center for Biotechnology Information)

General Introduction

Engages members of the international scientific community in informatics research and training through the Scientific Visitors Program

Develops, distributes, supports, and coordinates access to a variety of databases and software for the scientific and medical communities

Develops and promotes standards for databases, data deposition and exchange, and biological nomenclature

ncbi national center for biotechnology information2
NCBI(National Center for Biotechnology Information)

Entrez(Cross-Database Search System )

It is a powerful federated search engine, or web portal that allows users to search many discrete health sciences databases at NCBIwebsite.

slide17
General Introduction
  • Over 20 million citations from MEDLINE(1966-) and additional life sciences journals(1865-)
  • MEDLINE

+ PreMEDLINE

+ HyperLink

slide18
General Introduction
  • More than 80 countries,50 languages, 23.7 thousand journals
  • It`sFREE!!

HOW to USE

slide22
How do I search PubMed?
  • Identify the key concepts for your search.
  • Enter the terms (or key concepts) in the search box.
  • Click “Search” to run this search in PubMed.
slide23
Sample
  • 胃癌
    • Stomach Cancer
    • Stomach Tumor
    • Stomach Tumour
    • Stomach Neoplasm(s)

…………

…………

slide26
Journal Title、Publication Date

Authors

Title Words

Affilication

Search the same topic articles from Title\Abstract\MeSH

Unique Identifiers

Abstract

slide31
WHY there are so many articles not I want?

The garbage articles make me boring!!

slide32
More Exactly?
  • Stomach Cancer
    • Stomach Cancer
    • Stomach Tumor
    • Stomach Tumour
    • Stomach Neoplasm(s)

…………

…………

MeSH

Stomach Neoplasms

slide33
MeSH(Medical Subject Headings)
  • Controlled vocabulary of biomedical terms that is used to describe the subject of each journal article in MEDLINE
  • There are 26,142 descriptors in 2011 MeSH
slide36
Controlled

Standardized

subheadings
Subheadings
  • Narrow the specific focus of a main topical heading to a particular aspect of the subject.
  • There are 83 topical qualifiers
  • http://www.nlm.nih.gov/mesh/topsubscope.html
slide43
Tips
  • Operation—Surgery(Subheadings)
  • Drug/adverse effects
  • Therapy Method/adverse effects
  • Disease/complication
sample
Sample

Therapy or Nursing

on Stomach Cancer

slide53
Tips
  • Clinical Queries
  • Single Citation Matcher
slide60
Sample
  • 2008;5;387-?
slide61
2008

387

5

slide80
F1000 (Faculty of 1000)
  • Continuously updated selections and evaluations of the most important articles
  • Attributed opinions and expert knowledge from global leaders in biology and medicine
  • Site customization and email alerts based on user interests
  • Recommendations and interpretations based on the article's merits, not the journal's
slide83
Recommended

(6-7)

Must Read

(8-9)

Exceptional

10+

slide87
About the Literature √

About search √

slide89
Evaluation
  • F1000 or F1000m
  • SCIe
  • Jadad Scale
  • ……
slide96
Read
  • Title
  • Material & Method
  • Outcome
  • Discussion
  • ……
jadad scale
Jadad Scale

Jadad AR, Moore RA, Carrol D, et al. Assessing the quality of reports of randomized clinical trials: is blinding necessary [J] Control Clin Trials, 1996, 17:1–12.

jadad scale grade
Jadad Scale Grade
  • Full Mark: 5
  • High Mark : ≥3
  • Low Mark: <2

:easy, abroad

: lack of allocation concealment

jadad schulz
Jadad + Schulz
  • Adequate
  • Inadequate
  • Unclear

http://www.cochrane-handbook.org

slide100
e.g.

Title

Randomized clinical trial of intravenous soybean oil (豆油)alone versus soybean oil plus fish oil emulsion (乳剂)after gastrointestinal cancer surgery.

Jiang ZM, Wilmore DW, Wang XR, et al.

Br J Surg. 2010, 97(6):804-809.

slide101
e.g.Material & Method

R

DB

Reference:

Jiang ZM, Wilmore DW, Wang XR, et al. Randomized clinical trial of intravenous soybean oil alone versus soybean oil plus fish oil emulsion after gastrointestinal cancer surgery. Br J Surg. 2010, 97(6):804-809.

101

slide103
e.g.
  • Jadad
    • 随机:2分(文中描述了随机序列产生方法且方法恰当)
    • 双盲:2分(文中描述了实施双盲的方法且盲法恰当)
    • 退出与失访:1分(文中对退出的例数和理由进行了详细描述,无失访)
  • 此文总得分为5分,属高质量研究

103

slide104
e.g.Material & Method

Reference:

Jiang ZM, Wilmore DW, Wang XR, et al. Randomized clinical trial of intravenous soybean oil alone versus soybean oil plus fish oil emulsion after gastrointestinal cancer surgery. Br J Surg. 2010, 97(6):804-809.

104

slide105
e.g.
  • Schulz隐蔽分组
    • 此文中产生随机序列者(统计室)和决定分配序别者(配药护士)均未参与纳入患者的工作,也未参与研究过程以及结果的测量和分析,
  • 此文中隐蔽分组为充分(Adequate)

105

slide106
About the Literature √

About search √

About Evaluation √

About Read √

slide109
GoPubMed
  • Based on PubMed Database
  • Gene Ontology AND MeSH
  • Analysis
  • It`s FREE!!

www.gopubmed.com

slide127
循证医学数据库
  • Best Practice
  • Cochrane
  • MICROMEDEX
  • Pier
slide137
What is the Literature?

How to find ?

How to evaluate ?

How to read ?

How to analysis ?

How to manage ?

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