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b Oxidation. Energy from Fats. Overview. Just the first part is different!. Definition. b Oxidation – fatty acids are used to make Acyl-CoA molecules and broken down in mitochondria to make Acetyl-CoA molecules, which can enter the Krebs Cycle .

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b oxidation

b Oxidation

Energy from Fats

overview
Overview

Just the first part is different!

definition
Definition
  • b Oxidation – fatty acids are used to make Acyl-CoA molecules and broken down in mitochondria to make Acetyl-CoA molecules, which can enter the Krebs Cycle.
  • Acyl-CoA – temporary compound formed when coenzyme attaches to fatty acid
step 1 activation of fatty acids by acetyl coa
Step 1: Activation of Fatty Acids by Acetyl CoA

Note: 2P from ATP are utilized in this process

step 3 oxidation of acylcoa
Step 3: Oxidation of AcylCoA

1. FAD+ oxidizes the bond between C2 and C3

2. Adding water results in the addition of OH to C3

3. NAD+ oxidizes that OH to a carbonyl group

4. CoA cleaves the bond between C2 and C3

notes
Notes
  • C1 = alpha C (Ca) and C2 = beta C (Cb), hence the term beta oxidation
  • Products:
    • AcylCoA (which undergoes b oxidation again)
    • Acetyl CoA (which enters the Krebs cycle)
    • NADH and FADH2 (which are utilized by ETC)
atp yield
Example: Palmitate (16 C)ATP Yield

Palmitoyl CoA + 7FAD + 7NAD + 7CoA + 7H2O 8Acetyl CoA + 7FADH2 + 7NADH + 7H+

how much atp did palmitate yield
How much ATP did Palmitate yield?
  • 8 acetyl CoA enter citric acid cycle and give:
    • 24 NADH = 72 ATP (by oxidative phosphorylation)
    • 8 FADH2 = 16 ATP (by oxidative phosphorylation)
    • 8 GTP = 8 ATP
  • 7 NADH generated by beta oxidation itself =

21 ATP (by oxidative phosphorylation)

  • 7 FADH2 generated by beta oxidation itself =

14 ATP (by oxidative phosphorylation)

  • Total number of ATP from 1 molecule of palmitate =

72 + 16 + 8 + 21 + 14 = 131.

  • But REMEMBER:

we used to high energy phosphate bonds (equivalent of 2 ATP) to activate palmitate to palmitoyl CoA. Therefore, the ATP yield is 129.

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