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I.SULFONAMIDA GELMO 1908 (ABAD 20) DAMAGK 1932- 1935 500 SENYAWA SULFA ----- 30 SENYAWA

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I.SULFONAMIDA GELMO 1908 (ABAD 20) DAMAGK 1932- 1935 500 SENYAWA SULFA ----- 30 SENYAWA

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  1. B. ANTIBIOTIKAKLASIFIKASI ANTIBIOTIKA1.   BERDASARKAN CARA KERJAa.   HAMBAT SINTESA DINDING SEL : PENISILIN, BASITRASIN, NOVOBIOSIN, SEFALOSPORIN, VANCOMISIN DLLb.  MERUSAK MEMBRAN SEL: POLIMISIN,GENTAMISIN, NOVOBIOSIN DLLc.   HAMBAT SINSTESIS PROTEIN : TETRASIKLIN, KLORAMFENIKOL, NEOMISISN, STREPTOMISIN, ERITROMISIN, TILOSIN DLLd. HAMBAT SISTESIS ASAM NUKLEAT: AKTINOMISIN, QUINOLONE, SULFONAMIDA DLL

  2. 2. BERDASARKAN KEPEKAAN KUMANa.  KUMAN GRAM POSITIF (+) , PENISILIN, BASITRASIN, ERITROMISIN, TILOSIN DLLb.  KUMAN GRAM NEGATIF (-), STREPTOMISIN, NEOMISIN, KANAMISIN, GENTAMISIN DLL c.  ANTIB. SPEKTRUM LUAS, AMPISILIN, TETRASIKLIN, KHLORAMFENIKOL, SULFONAMIDA DLL

  3. 3.BERDASARKAN KEMAMPUAN ANTIBIOTIKA TERHADAP KUMAN DAN PERTUMBUHANa. BAKTERISIDAL : PENISILIN, STREPTOMISIN, BASITRASIN, NEOMISIN, NITROFURAN DLLb. BAKTERIOSTATIK: TETRASIKLIN, KHLORAMFENIKOL, ERITROMISIN, TILOSIN,ELEANDOMISIN, SULFA DLL

  4. 2. BERDASARKAN KEPEKAAN KUMANa.KUMAN GRAM POSITIF (+): PENISILIN, BASITRASIN, ERITROMISIN, TILOSIN DLLb.KUMAN GRAM NEGATIF (-): STREPTOMISIN, NEOMISIN, KANAMISIN, GENTAMISIN DLL c.ANTIB. SPEKTRUM LUAS: AMPISILIN, TETRASIKLIN, KHLORAMFENIKOL, SULFONAMIDA DLL3.BERDASARKAN KEMAMPUAN ANTIBIOTIKA TERHADAP KUMAN DAN PERTUMBUHANa.BAKTERISIDAL: PENISILIN, STREPTOMISIN,BASITRASIN, NEOMISIN, NITROFURAN DLLb.BAKTERIOSTATIK: TETRASIKLIN, KHLORAMFENIKOL, ERITROMISIN, TILOSIN, ELEANDOMISIN, SULFA DLL

  5. I.SULFONAMIDA GELMO 1908 (ABAD 20) DAMAGK 1932- 1935 500 SENYAWA SULFA ----- 30 SENYAWA ANTIB. EFEK SAMPING --- SULFA GABUNGAN STRUKTUR DAN SIFAT KIMIAWI SO2 NH2 R2= PTALAT, SUKSINAT R1= GARAM NATRIUM SEDIAAN SULFA : SULFATHIAZOLE, SULFAPYRIMIDINE, SULKFAMERAZINE, SULFAMETHAZINE, SULFASOXASOLE, SULFADIMETHOXINE, SULFAQUINOXALINE, SULFAGUANIDINE DLL

  6. SIFAT SULFA :SULIT LARUT DALAM AIRCAMPURAN 2 SULFA CEPAT LARUT DI AIRPH TINGGISULFAPYRIMIDINE LARUT RENDAHSUBST R1 (ALKYL) DENGAN NATRIUM (Na) MENJADI GARAM --- LARUT TINGGI KONDISI TERNAKSIFAT ANTIBAKTERISIDALDOSIS RENDAH BAKTERIOSTATIKDOSIS TINGGI BAKTERSIDALHAMBAT SINTESIS PROTEINPABA (PARA AMINO BENZOAT ACID)KOMPETISI DENGAN SULFA AS. THIMIDILAT, PURIN, HISTIDIN, METHIONINHAMBAT SINTESIS DNADIHIDROFOLATE REDUKTASE SEDIAAN SULFA EFEKTIFGRAM POSITIF \GRAM NEGATIF

  7. ABSORBSI, MET, DISTRIBUSI, EKSKRESIDI USUS ABSORBSI 50-90%PH 6-8 (RUMEN)METABOLISME DI HATI, KHUSUS KAMBING DI KELJ SUSUIKATAN SULFA DENGAN PROTEIN DARAH ALBUMIN 10%, SULFAMERAZINE DAN SULFATHIAZOLE 70% SEDANGKAN SULFABROMOTHIAZOLE 90%DISTRIBUSI KESEMUA JARINGAN TUBUH, WITHDRAWAL TIME 5 – 15 HARIEKSKRESI : GINJAL, EMPEDU, TINJA, KERINGAT DAN AIR SUSUTOKSISITAS SULFONAMIDA BERKAITAN DENGAN :GANGGUAN GINJALHIPOPROTROMBINEMIAGANGGUAN PARENKIM HATI

  8. KERACUNAN KRONISPERTUMBUHAN TURUNAGRANULOSITOSISASIDOSIS, CaCo3, TELUR TIPISMETHEMOGLOBINEMIAREAKSI IMUNOLOGIK, URTIKARIAEFEK GOITROGENIK (TIKUS)GANGGUAN REPRODUKSI (LITER SIZE, ATROP[I TESTIS, PROSTAT)SULFA DRUG

  9. CONTOH :SULFAGUANIDINE 0,5 % 3-5 HARISULFAMERAZINE 2-4 GR/ GLN 2-6 HARISULFADIMETHOXINE 1,5 GR/GLN 6 HARISULFABENZAMIDE 3,5 GR/GLN 4-5 HARISULFA KOMBINASI :SULFAQUINOXALINE + DIAVERIDINESULFADIMIDINE + TRIMETHOPRIMESULFAMETHAZINE + NEOMISINE SULFATKOKSIDASIS/KOKSIDIOSISSODIUM SULFAQUINOXALINE 3,62 GR% 30 ML/ 4 L AIR 2.3.2 45 ML/4 L AIR 2.3.2 / 3.2.3SULFADIMIDINE 500 MG/PYRIMETHAMINE 50 MG 0,5 GR/ L AIR 3.2.3SULFADIMIDINE 200 MGTRIMETHOPRIME 15 MG 1 ML / L AIR 2 ML/ L AIR

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