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INTOKSIKASI ORGANOFOSFAT

INTOKSIKASI ORGANOFOSFAT. SYAIFUL AZMI Bagian Ilmu Penyakit FKUA/ RS Dr. M. Djamil PadangDalam. PENDAHULUAN. Organofosfat (Parathion, Malathion ) Cholinesterase inhibitor Aktifitas Asetil Kolin Merangsang reseptor nicotinic, muscarinic dan SSP. Tempat masuknya racun. Oral Inhalasi

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INTOKSIKASI ORGANOFOSFAT

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  1. INTOKSIKASI ORGANOFOSFAT SYAIFUL AZMI BagianIlmuPenyakit FKUA/ RS Dr. M. DjamilPadangDalam

  2. PENDAHULUAN • Organofosfat (Parathion, Malathion) • Cholinesterase inhibitor AktifitasAsetilKolinMerangsangreseptornicotinic, muscarinic dan SSP

  3. Tempatmasuknyaracun • Oral • Inhalasi • Kulit • Mukosa

  4. PENYEBAB • Bunuhdiri • Kecelakaan • Pembunuhan

  5. Gambaranklinis • Gejala • Dindingperuttegang • Diare • Muntah • Salivation • Keringat • Lacrimation

  6. Gambaranklinis • Pemeriksaanfisis • Muntahbauorganofosfat • Miosis • Bradikardi • Bronkhospasme • Sekresibronkhus Respiration arest

  7. LAB : AktivitasCholin Esterase DieritrositSp 50%

  8. TERAPI • Emergensi • Airway • Infus, koreksiasambasa, elektrolit

  9. Dekontaminasi • Sal Cerna ( < 3Jam) • Pengencerandengan air dingin / susu • Induksimuntah (stimulasiorofaring) • Aspirasidankubahlambung (NGT) • Arangaktif 30-50 grdl 240 cc Air • Mata • Miringkankepala • IrigasidenganNaClFisiologisTutupmata

  10. Dekontaminasi • Inhalasi • Jauhkanpenderitadarilokasi • Kulit • Lepaskanpakaian,arloji, sepatudll • Mandidengan air mengalirdansabun

  11. DIURESIS PAKSA

  12. SULFAS ATROPIN • 1-2 mg tiap 10-15 detik max 50 mg/Hr • Sampaiterdapattanda-tandaatropinisasidosisdikurangiperlahan-lahan • Tanda-tandaatropinisasi • Mukamerah • Takikardi • Midriasis • Mulutkering

  13. ANTI DOTE • Pralidoxime (2-Pam protopam) dapatmengikatorganofosfat

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