Speakers and topics. Hilton J. Klein, M.S., V.M.D. Overview and introduction Kathryn A. L. Bayne, M.S., Ph.D., D.V.M. Review of commonly cited facility problems James F. Taylor, D.V.M., M.S. Design of facilities - the AAALAC perspective Stephen T. Kelley, M.S., D.V.M.
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Conclusion: renovations or construction will require systems for information management access and retrieval for effective colony and facility management.
"Performance standards define an outcome in detail and provide criteria for assessing that outcome, but do not limit the methods by which to achieve that outcome."
… in 18 countries
1. Data not available at site visit
2. Not maintaining temperature range
3. Not maintaining air changes (ventilation)
4. Not maintaining humidity range
5. Not meeting recirculated air standards
6. Animal room temperature and humidity not monitored
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Site visitors conducted a site visit at a respected, small research institute conducting infectious disease studies involving Biosafety Level 2 agents. There were a total of six (6) animal rooms housing either rats or mice. The HVAC report below was provided as an attachment to the program description.
All rooms were sanitized at weekly intervals by wet-mopping the floor and wiping the walls down with an appropriate mild quaternary ammonium disinfectant. Cages were sanitized appropriately twice weekly. Bedding was also changed once in a hood between cage sanitation cycles. Upon entering the rooms, site visitors observed the following cage and stocking densities …
A site visit to a large university biomedical research program indicated that a small colony (n=25 adults) of macaques was housed in the top floor of a “satellite” building. The research involved behavioral testing and brain imaging which was conducted in separate laboratories within the same building. The behavioral test lab and the imaging lab were accessible only by an elevator which was also used to transport non-laboratory personnel. Cage washing facilities were located in the basement of the building.
Upon careful review of the written Program Description, site visitors concluded that after-hours monitoring of the animal rooms in a 45 year old animal facility consisted of: a) recording the high-low temperature readings in the room on a log sheet by the animal caretaker, and b) the security guard making rounds to ensure the corridor and hallway doors are closed. This process was confirmed during the site visit.
Additional background information revealed a steam injector valve in the room humidification control system had stuck in the open position overnight six months prior to the site visit. This room housed 50 rats on a respiratory/inhalation study at the time. Animal care staff realized the room temperature had reached 105ºF overnight because of the steam valve defect. Fifteen animals were found dead the next morning. Within two days, the study was terminated because of twenty (80%) percent mortality in the controls and test animals. Excessive respiratory problems were observed in the remaining animals which invalidated the study.