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The study explores how B10 cells utilize IL-10, IL-21R, CD40, and MHC-II expression to modulate EAE severity. Understanding these regulatory pathways can aid in developing targeted therapies for autoimmune diseases.
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B10 cells require IL-10, IL-21R, CD40 and MHC-II expression to regulate EAE severity. A Yoshizaki et al. Nature000, 1-5 (2012) doi:10.1038/nature11501