The ketogenic diet. properties. high-fat, adequate-protein, low-carbohydrate diet . The diet forces the body to burn fats rather than carbohydrates.
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The diet forces the body to burn fats rather than carbohydrates.
The original therapeutic diet provides just enough protein for body growth and repair, and sufficient calories to maintain the correct weight for age and height. This classic ketogenic diet contains a 4:1 ratio by weight of fat to combined protein and carbohydrate. This is achieved by excluding high-carbohydrate foods.
the liver converts fat into fatty acids and ketone bodies. The ketone bodies pass into the brain and replace glucose as an energy source.
broad anticonvulsant effects, as it is able to control seizures of many different types. In this way it is a more effective anticonvulsant therapy than any of the currently available antiepileptic drugs
Ketogenic diet is used as a second line treatment for refractory epilepsy ( don’t respond to 2-3 different anticonvulsants).
the10 mM concentration of acetoacetate directly dialyzed into the rat brain was considerably higher than the effective concentrations required for inhibition of VGLUT2
organotypic hippocampal slice cultures chronically exposed to BHB were not protected from pharmacologically induced epileptiformactivity.
acetoacetate rapidly breaks down to acetone or is converted to BHB, so it remains to be shown whether acetoacetate levels in the brain during dietary therapy are sufficient to inhibit VGLUT2 chronically