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Fluid Distribution and Electrolyte Balance in Adult Human Body

Learn about the compartments of body fluid and electrolyte distribution in a 70 kg adult human, including ICF, ECF, interstitium, and plasma volumes. Understand the impact of osmolality changes on body fluid dynamics.

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Fluid Distribution and Electrolyte Balance in Adult Human Body

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  1. Infusion 70 kg adult

  2. Sample Problem A subject weighs 80 kg. Calculate the volumes of the ICF, ECF, interstitium and plasma. Total Body Water: 80 kg x 0.60 = 48 liters ICF: 80 kg x 0.40 = 32 liters ECF: 80 kg x 0.20 = 16 liters Interstitium: 16 liters x 0.75 = 12 liters Plasma: 16 liters x 0.25 = 4 liters

  3. Total body‘s fluid = 0.6 · body`s weight 42 l 2/3 1/3 Extracellular fluid (ECF) Intracellular fluid (ICF) 28 l 14 l Cell membrane 3/4 1/4 Interstitial fluid Plasma 3.5 l 10.5 l Capillary endothelium Distribution of fluid of the body

  4. Cations Anions 150 100 ECF mEq/l 50 Na+ Cl- HCO3- 0 0 Ca2+ K+ Proteins Mg2+ 50 PO43- and organic anions mEq/l ICF 100 150 Distribution of electrolytes

  5. 300 300 ICF ECF ICF ECF 200 200 Osmolality (mOsm/kg H2O) 2 L isotonic NaCl 100 100 0 0 30 20 10 0 10 20 30 20 10 0 10 20 Volume (L) 290 mmol NaCl 2 L H2O 300 300 ICF ECF ICF ECF 200 200 100 100 0 0 30 20 10 0 10 20 10 20 30 20 10 0 Changes in body fluid by addition of solutions of different Osmolality 290 mmolNaCl = 580 mOsm

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