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AKT1

?. InsR. P. P. PI3K. P. PIP2. PIP3. P. MAPKKK. PTEN. P. ?. PDK1. P. MAPKK. P. P. AKT2. MAPK. P. P. AKT1. SGK1. P. P. SKN-1. P. P. miRNA. FOXO. miRNA. SKN1. FOXO. stress response genes innate immunity genes longevity genes. InsR. ?. 1. P. P. P. PIP2. PIP3.

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AKT1

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  1. ? InsR P P PI3K P PIP2 PIP3 P MAPKKK PTEN P ? PDK1 P MAPKK P P AKT2 MAPK P P AKT1 SGK1 P P SKN-1 P P miRNA FOXO miRNA SKN1 FOXO stress response genes innate immunity genes longevity genes

  2. InsR ? 1 P P P PIP2 PIP3 P ? P P 1a P P P P P P P P miRNA SKN-1 miRNA FOXO 2 3 SKN1 FOXO stress response genes innate immunity genes longevity genes

  3. InsR ? 1 P P P PIP2 PIP3 P ? P P 1a P P P P P P P P miRNA SKN-1 miRNA FOXO 2 3 SKN1 FOXO stress response genes innate immunity genes longevity genes

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