MRI ICAD 2010. Outline. ADNI 1 - Summarize most important results – internal and external ADNI investigators From ISAB summary of reasoning and pilot work behind final GO/ADNI 2 protocol Summarize QC procedures for new sequences Summarize parameters of sequences.
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Dx, prediction, rates of change, sample size
Jack et al, Lancet Neurol 2010; 9: 119-28
Ab Amyloid = CSF Ab42 or amyloid PET imaging; Tau Mediated Neuron Injury and Dysfunction = CSF tau or FDG PET; Brain Structure = structural MRI
Annual change in global PIB ratio and ventricular volume by clinical diagnosis
PIB positive subjects (baseline global cortical PIB ≥ 1.5)
are represented with triangles and PIB negative subjects (baseline global cortical PIB < 1.5)
are represented with circles.
Jack et al, Brain 2009 132 (Pt 5):1355-65
ADNI: Predicting time to conversion from MCI to AD from baseline biomarkers – univariately Vemuri et al Neurology 2009
Vemuri et al, ePub Annals of Neurology, 2010
Metric is sample size per arm to detect a 25% rate reduction in AD – question is, do image corrections reduce technical variance in a meaningful way?
Each MRI exam will contain both an accelerated and a non-accelerated 3D T1 acquisition – * not back-to-back, (3.6%) exam “salvage rate”
Phillips MPRAGE unaccel 9:06 baseline biomarkers – univariately
Phillips MPRAGE accel 5:35
GE MPRAGE (ADNI-1) 9:17
GE IR-FSPGR (ADNI-GO) 9:41
GE IR-FSPGR (ADNI-GO) 5:34
Long TE gradient echo scan baseline biomarkers – univariately
From Kantarci et al, in press Neurology
Page 1 of 10 baseline biomarkers – univariately