1 / 8

Cutaneous Carcinosarcoma

Cutaneous Carcinosarcoma. Department of Medicine, Division of Hematology/ Oncology, Department of Pathology Department of Surgery, Division of Surgical Oncology Feinberg School of Medicine, Northwestern University, Chicago, IL.

duncan-brewer
Download Presentation

Cutaneous Carcinosarcoma

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Cutaneous Carcinosarcoma Department of Medicine, Division of Hematology/ Oncology, Department of Pathology Department of Surgery, Division of Surgical Oncology Feinberg School of Medicine, Northwestern University, Chicago, IL Katy H. Goldsborough, William B. Laskin, Jeffrey D. Wayne, Mark Agulnik

  2. Carcinosarcomas (CS): Background • Malignant neoplasm • Biphasic epithelial and mesenchymal elements • Breast, lung, urogenital, gastrointestinal • Hypothesis- Multiclonal vs. Monoclonal • IHC studies establish 2 distinct populations • Primary cutaneous CS • Dawson 1972 • Basal and squamous cell carcinoma • Pleomorphic/ atypical fibroxanthoma/ MFH

  3. Case Report • 62 y.o. male • Subcutaneous 4 mm nodule lateral to sternum • Slow growth over 18 months • Excisional bx followed by wide local excision

  4. Methods • All case reports and series of CCS • Search terms: • Carcinosarcoma • Carcinoma and sarcoma • Sarcomatous sarcoma • Biphasic sarcomatoid carcinoma • Spindle cell carcinoma • 48 publications reviewed

  5. Results • Between 1972 and 2007: 74 cases of CCS have been reported.

  6. Results

  7. Conclusions • Primary CCS is a rare disease. • 6th-8th decade of life • Survival predicted by: • Epithelial component • Growth pattern • Tumor size • Duration • LN involvement • Age

  8. Conclusions • Treatment approach • Wide local excision • Negative margins • No defined role for adjuvant radiation therapy or chemotherapy.

More Related