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Mechanism of antibiotic resistance explained by Dr Sheetu Singh Chest specialist in Jaipur

Mechanism of antibiotic resistance explained by Dr Sheetu Singh Chest specialist in Jaipur<br>www.drsheetusingh.com

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Mechanism of antibiotic resistance explained by Dr Sheetu Singh Chest specialist in Jaipur

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  1. Mechanism of resistance • When antibiotic is used in a patient with a certain illness it kills the susceptible bacteria and leaves behind RESISTANT bacteria • With reduced competition the resistant bacteria proliferate and grow in number • Broad spectrum antibiotics kill large number of bacteria and promote resistance

  2. Proportion of Resistant Invasive Streptococcuspneumoniae spp., 1992-2008 Percent Fully Resistant Source: CDC Active Bacterial Core Surveillance and Sentinel Surveillance Network. • Erythromycin resistance data not available

  3. Mechanism of antibiotic resistance

  4. High affinity for PBP Inactive PBP Inhibition of peptidoglycan synthesis Cell wall destruction Bacterial death

  5. ß - Lactam • More use • Under-dose • Inadequate duration • Inappropriate use

  6. Low affinity for PBP Active PBP Normal peptidoglycan synthesis No cell wall destruction No bacterial death Antibiotic resistance

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