1 / 8

Fungi are the cells that fill the gap between life and death.– Paul Stamets

Mucormycosis or black fungus is a rare fungal infection that is being reported in covid recovered patients in various states in India.

drashesh
Download Presentation

Fungi are the cells that fill the gap between life and death.– Paul Stamets

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Fungi are the cells that fill the gap between life and death.– Paul Stamets

  2. CovidAssociated Mucormycosis: Not a Black Fungus!! Is Mucormycosis infections after Covid a Black Fungus infection? In the Covid- 19 pandemic, CAM (Covid Associated Mucormycosis) is incorrectly referred to as Black Fungus. There is no scientific journal dealing with diseases caused by Mucormycosis as a Black Fungus infection. Dermatiaceous fungi, not Mucormycosis, cause black fungus. ROCM (Rhino Orbital Cerebral Mucormycosis) is another term for CAM, not BlackFungus.

  3. Who can be harmed by CAM/ROCM: Diabetics above the age of 65, a history of high-dose, long-term steroid treatment, Recovering from a Covid infection ( 2-4 weeks prior), Cancerous tumor, Immunosuppressive medications, long-term ventilator/oxygen treatment Usage of to cilizumab/immunomodulatorsHemochromatosis is a form of hemochromatosis. When to suspect CAM: Facial pain/discoloration/swelling, Eye -dropping eyelid/eye bulge (ptosis/proptosis/EOM limited, reduced vision), Stuffiness, unpleasant odor, nasal discharge, discoloration of the nose, and nose bleeding ( epistaxis), PAIN- Headache, tooth pain Fever, distorted sensorium, and paralysis are all symptoms. Where in doubt, get a second opinion. Suspicion is high, and the diagnosis is made early. How to Recognize CAM: Nasal endoscopy, Deep Nasal Swab, CT, and MRI imaging are all options. Is it a true emergency: Is that correct? If treated early, the result is favorable. If left unchecked, 50% of patients will go blind or die. Who is capable of treating it: Show it to your primary care physician, who will recommend you to an ENT surgeon/Eye surgeon or Neurologists/Neurosurgeon/Combined team depending on the severity of the condition. Will it be treated at home if diagnosed?  No, hospitalization is needed to validate the diagnosis and to begin medical/surgical care as soon as possible.

  4. DematiaceousHyphomycetes It cause Phaeohyphomycosis. Because of the inclusion of melanin in their cell wall, these fungi are darkly pigmented. Infections of these fungi can be clustered at the site of the painful inoculation or inside the sinuses, or they can spread.

  5. MucorFungus It causes Mucormycosis in Covid 19, is found in soil, compost, animal dung, decaying wood and plant material, fruits, and vegetables. It is common and can be detected in the dirt, air, and even good people's noses and mucus. If left unchecked, mucormycosis has a 50% mortality rate.

  6. Medical Management: Liposomal Amphotericin B 5mg/kg/day for 4 weeks, followed by Oral Posaconazole 300mgBD on day 1 and either 300 mg Od for 4 weeks (depending on the clinical response) or Isovucanazole ( 200mg OD for 4 -6 weeks) MEDICATIONS USED TO TREAT IT  Surgical treatment: Includes early comprehensive sinus debridement and nasal irrigation by an ENT surgeon, orbital exenteration if indicated, and neurosurgery if the intracranial distribution occurs.

  7. Is CAM exclusive to the Covid-19 Pandemic: No, it does not. Mucormycosis infections were first documented in the medical literature before the Covidpandemic. In high-risk Covid patients, higher CAM infections in the second wave of Covid -19 are linked with indiscriminate/non judicious use of steroids and oxygen therapy. Is CAM caused by industrial oxygen supply: Covid'sfirst wave did not have as many Mucormycosis cases? The increase in ROCM in the second wave, as well as the correlation with high-dose steroids and industrial oxygen use, are being considered. Data is being analyzed. However, the condition has been observed in people who were not receiving oxygen therapy. How to prevent CAM To prevent CAM, avoid using steroids/tocilizumabindiscriminately. Gargle with betadine. There will be no nasal drops. Sterile asepsis during oxygen treatment, sterile water for a humidifier, and humidifier tubing replacement regularly. Mask as a barrier. DM is being aggressively monitored and regulated. Oral Posaconazole can be seen in high-risk populations (> 3 weeks of breathing or oxygen treatment, > 3 weeks of steroids, untreated diabetes).

More Related