1 / 9

TTGACATACCCGTAAT

TTGACATACCCGTAAT. What would the complementary strand of this DNA molecule read? AACTGTATGGGCATTA. ATGACGGTACAAGGACGTACTAACTCCCATCGATCTAGTCTAGGTCTA. What is the mRNA transcript for this sequence of DNA? -UACUGCC AUG UUC CUG CAU GAU UGA GGGUAGCUAGAUCAGAUCCAGAU

drake
Download Presentation

TTGACATACCCGTAAT

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. TTGACATACCCGTAAT • What would the complementary strand of this DNA molecule read? • AACTGTATGGGCATTA

  2. ATGACGGTACAAGGACGTACTAACTCCCATCGATCTAGTCTAGGTCTA What is the mRNA transcript for this sequence of DNA? -UACUGCC AUG UUC CUG CAU GAU UGA GGGUAGCUAGAUCAGAUCCAGAU Which proteins would the mRNA code for? - Start – Phen – Leu – Hist – Asp – STOP

  3. Mutations Are all mutations a bad thing? A change in the genetic material of a cell. No, they can be detrimental, but they can also be positive or neutral (no effect on the organism)

  4. Types of mutations • Chromosomal - changes in chromosome structure or number of chromosomes • Translocation – segment of one chromosome is attached to another one • Inversion – segment of a chromosome breaks off, flips over and reattaches • Addition or deletion of an entire chromosome caused by Non-disjunction Example: down syndrome (an extra 21st chromosome)

  5. Gene Mutations – chemical changes in the DNA. • Substitution – replacement of one nucleotide pair (A,C,T or G) with another. Often time this has no effect. Sometimes this will lead to an improved protein or be detrimental (like sickle cell anemia or cystic fibrosis).

  6. What would happen to the translation process if one nucleotide were not transcribed (copied into mRNA) correctly? Give at least three possibilities • mRNA would not be translated into a protein because the start codonwas affected • Too much information got translated because a stop codonwas affected • There is no effect because the nucleotide was not in between start and stop codons

  7. Mutations had no effect on the protein TACAAGGACGTACTAACT AUG UUC CUG CAU GAU UGA Start – Phen – Leu – Hist – Asp – STOP TACAAGGACGTGCTAACT AUG UUC CUG CAC GAU UGA Start – Phen – Leu – Hist – Asp – STOP

  8. Insertion and deletions – adding or losing a nucleotide pair. This is more dramatic than a substitution because it usually leads to a frameshift mutation, where the entire gene could be changed.

  9. Mutation caused a different protein to be made TACAAGGACGTACTAACT AUG UUC CUG CAU GAU UGA Start – Phen – Leu – Hist – Asp – STOP TACAAGGACGTACCTAACT… AUG UUC CUG CAU GGA UUG A… Start – Phen – Leu – Hist – Gly – Leu…

More Related