THE KREB’S CYCLE What Goes Around Comes Around. The Krebs Cycle What Goes Around Comes Around. Part 1: Preparation of Pyruvate. Mitochondria Outer Membrane. Cytosol. Mitochondria. NAD+. NADH. (2C) Acetic Acid. H. CO 2. Coenzyme A. Acetyl – Coenzyme A. Pyruvate (3C).
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What Goes Around Comes Around
The Krebs Cycle What Goes Around Comes Around
Part 1: Preparation of Pyruvate
Mitochondria Outer Membrane
Acetyl – Coenzyme A
Part 2: Kreb’s Cycle
THE KREB’S CYCLE
1 X 2 = 2
4 X 2 = 8
1 X 2 = 2
3 X 2 = 6
Kreb’s Cycle Song
melody and lyrics by Lynda Jones; adapted by Do Peterson and Greg Crowthe
Greg: geek vocals, keyboard Lori: lead vocals Kirk L. Van Scoyoc: banjo
Do: bass, hyper-dramatic vocals, keyboard, acoustic and electric guitar, drum
Acetyl CoA combines with oxaloacetic acid
To create a citric acid. That's how it begins.
Then a water removed and added makes it isocitric acid,
Which, in turn, oxidized and loses CO2.
Then alpha-ketoglutaric is oxidized again,
Losing carbon dioxide with an NADH spin.
Then through a phosphorylation
Succinyl CoA congeals a GDP to GTP to toss back CoASH.
CHORUS:Acetyl CoA, citric acid, iso-,Alpha-ketoglutaric, succinyl CoA,Succeeded by succinic, fumaric and malic,Then oxaloacetic starts the cycle again.
Soon we see succinic acid forming a fumaric acid
As it forms an FADH2 along the way.
Water washed upon fumaric makes it into acid malic.
Now there's only one step left, so let's be on our way.
With one more oxidation, resisting degradation,
A final NADH is made and brings us to the end.
Oxaloacetic acid, first and last, a simple acid
Then accepts an acetyl CoA and starts again.