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Impact of Housing and Sleep Deprivation on Brain Injury Recovery in Rats

This pilot study investigates how prior housing conditions and sleep deprivation influence recovery from brain injury in rats. The average lesion size was measured across all experimental groups using cresyl violet-stained sections, revealing that the sham-only group exhibited significantly different outcomes compared to all others (p < 0.01). However, no significant differences were found among the controlled cortical impact groups. Findings suggest that environmental factors play a critical role in recovery processes following brain injuries.

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Impact of Housing and Sleep Deprivation on Brain Injury Recovery in Rats

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  1. Figure 3. Percent lesion volume for all experimental groups. Average lesion size for each group calculated from cresyl violet-stained sections through entire lesioned area. Sham-only group was significantly different from all groups (p < 0.01). No significant differences were found among three other controlled cortical impact (CCI) groups. Error bars represent standard error. NH = normal housing, SD = sleep deprivation. Riechers RG, Shuster JL, Bryan KJ, Burant CJ, Ball SL. Prior housing conditions and sleep loss may affect recovery from brain injury in rats: A pilot study. J Rehabil Res Dev. 2013;50(4):455–62.http://dx.doi.org/10.1682/JRRD.2012.04.0061

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