Ethanol. Ethanol Acetaldehyde PEth ROS Others. RTK. GPCR/ G-proteins. Src. Acetaldehyde. Ras-raf. PKC. PEth. ROS , others. MEK 1/2. Acetate. p38 MAPK. p42/44 MAPK. JNK1/2. Caspases. ?. p42/44 MAPK. JNK1/2. p38 MAPK. MSK 1/2. Histone/chromatin modification
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ROS , others
(acetylation, phosphorylation etc.)
(NFkB, AP1, CREB etc.)
Apoptosis Inflammation Proliferation Differentiation