Hemostasis: An In-depth Overview of Coagulation Factors & Thrombolytic Therapy
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Explore the components of hemostatic systems, from primary to secondary hemostasis, focusing on Coagulation Factors I, V, VIII, XIII, and more. Discover the role of platelets in blood clotting and thrombolytic treatments for specific conditions.
Hemostasis: An In-depth Overview of Coagulation Factors & Thrombolytic Therapy
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Presentation Transcript
HEMOSTAZ Yard. Doç. Dr. Murat ÖRMEN
SUNUM PLANI • Hemostaza genel bakış • Hemostatik sistemlerin bileşenleri • Primer hemostaz • Sekonder hemostaz
Coagulation Factors • Fibrinogen Group • Factors I, V, VIII and XIII • Prothrombin Group • Factors II, VII, IX and X • Contact Group • Factors XI, XII • Prekallikrein (Fletcher Factor) • High Molecular Weight Kininogen • (Fitzgerald Factor)
• t-PA • Streptokinase • Urokinase • Anaphylaxis • GI Bleeding • Intracranial Hemorrhage Thrombolytic Therapy
Dense Body ADP Serotonin ATP Calcium Dense Tubular System Microtubular System Plasma Membrane PF3 Glycogen Exterior Coat (Glycocalyx) Alpha Granules PF4 Fibrinogen Factor V Fibronectin Factor VIII R:ag b Thromboglobulin (vWF) Mitochondria Surface Connecting System Cytosol Factor XIII Anatomy of a Platelet
Platelet Function A Adhesion ADP Release Shape Change Release 3 seconds Aggregation B 10 seconds C Coagulation Fibrin Formation 5 minutes