بنام خداي زيبائيها
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بنام خداي زيبائيها. Major Histocompatibility complex OR. MHC. MHC. The principal function of T cells are : Defense against intracellular microbes Activation of other cells(B cells ,Macrophages ) peptide recognition by T and B cells is different.

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6735817
MHC

  • The principal function of T cells are :

    Defense against intracellular microbes

    Activation of other cells(B cells ,Macrophages )

  • peptide recognition by T and B cells is different.

    B cells recognize soluble as well as cell associated Ags

    In contrast ,T cells recognize peptide which is displaying only by APC in associated with MHC proteins.


6735817
MHC

  • MHC genes are the most polymorphic genes

  • MHC genes are codominantly expressed in each individual

  • There are two main type of MHC:class I & II

  • The physiologic function of MHC molecules is presentation of peptides to T cells ,control of immune responsiveness to all proteins and graft rejection

  • MHC-I present cytosolic peptides to T cytotoxic cells and MHC-II present endocytosed peptides to Thcells






Polymorphism of class ii
Polymorphism of class II

  • HLA-DPA 12

  • HLA-DPB 88

  • HLA-DQA 17

  • HLA-DQB 42

  • HLA-DR >400


Polymorphism of class i
Polymorphism of class I

  • HLA-A >280

  • HLA-B >500

  • HLA-C >130






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