Management of Suspected Transfusion Reactions

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In the event of a suspected transfusion reaction, stabilize the patient immediately and notify the attending physician. Complete the clerical check and fill out the Transfusion Reaction form, then contact the Blood Bank. If the patient exhibits only itching and hives, other symptoms should resolve before resuming the transfusion, ideally after administering diphenhydramine. For further evaluation, draw two purple top tubes and send them to the Blood Bank with the remainder of the blood unit. If hemolysis symptoms are present, send a urine sample for analysis. Await pathology approval before transfusing another unit, unless urgent.

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Jan 05, 2026

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Management of Suspected Transfusion Reactions

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STOP Transfusion Transfusion Reaction Suspected - Stabilize patient - Notify attending - Perform Clerical Check Fill out TrxnRxn form & call Blood Bank Itching and hives only All other symptoms Trxn can resume AFTER symptoms resolve (Rx with diphenhydramine) Draw 2 purple tops and send to BB with remainder of unit for trxnrxnwork-up. Send urine if s/s of hemolysis. Unless emergent, wait for results and pathology approval to transfuse another unit. * Not all signs and symptoms may be present 2013 UNMH Transfusion Service (Ramos, Reyes, Crookston & Koenig)