Environmental Health Carcinogenesis. Week 7. Genotoxicity: toxic effects on genetic material. Cancer Developmental (gestational timing crucial) Somatic diseases . The nature of “life information”…. DNA structure Base-sugar-triphosphate Purines: A, G; Pyrimidines: C, T(U)
Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.
(gestational timing crucial)
(insertion/deletion of part of gene)
(x/ -rays, <10-10m; , particles)
See also p. 64 and 262 of Casarett and Doull’s “Toxicology”
Years of Life Lost*
584,000Cancer is the leading disease-related cause of years of life lost in the US.
* Estimated years of life lost before the age of 65
Cancer is therefore the malignant uncontrolled proliferation of neoplastic cells.
Also a description of a multitude of different disease states (~200)
Malignant neoplasms are usually called
carcinomas (endo- or ectoderm) or sarcomas
(mesoderm). Exceptions are hematopoietic
malignancies, melanoma, neuroblastoma, thymoma.
is key to carcinogenicity (1950’s)
and form adducts which can generate mutations
See also p. 267, 271, 275 of Casarett and Doull’s “Toxicology”
Polyaromatic hydrocarbons (PAHs) are initiating agents in tumor development
TPA is the experimental
skin tumor promoter
found in croton oil
doses of 2-acetylaminofluorene
of dimethylbenzanthracene and promoted with
See also p. 301 of Casarett and Doull’s “Toxicology”
of Neoplastic Progression
By B. Vogelstein