Objective

1. Does physical functioning as assessed by SF-36 predict peak oxygen uptake in patients with atrialseptal defect type secundum? Alexander Van De Bruaene*, Roselien Buys°, Luc Van Hees°, Philip Moons $, Werner Budts*. *Department of Cardiology, °Department of Rehabilitation Sciences, $Department of Health Services and Nursing Research, University Hospitals Leuven, Belgium. Objective Patients with congenital heart disease usually overestimate their exercise capacity as measured by cardiopulmonary exercise testing because of long-term adaptation. Most patients with atrialseptal defect (ASD) type secundum present with New York Heart Association (NYHA) classification I or II, making it difficult to estimate actual exercise capacity. Therefore, a perceived health status questionnaire may be more sensitive to detect physical and mental limitations in ASD patients. This study investigated the correlation between perceived health status and actual exercise capacity in open and closed ASD. Figure 2: Comparison peak oxygen consumption (peak vO2) and peak oxygen pulse (mL/beat) between ASD patients and age and gender matched controls shows limitations in exercise capacity in both patients with open and closed ASD when compared to age/gender matched controls Methods Figure 1: Flowchart study design Age/Gendermatched Controls N=12 Open ASD N=12 SF-36 CPET Recruitmentoutpatient ACHD clinic ASD patients N=33 CPET ACHD:Adult congenital heart disease CPET: Cardiopulmonary exercise test SF-36: Short Form 36 health questionnaire Closed ASD N=21 Age/Gendermatched Controls N=21 SF-36 CPET CPET Table 2: Correlations between SF-36 variables and peak oxygen consumption (peak vO2) in patients with open and closed ASD. Variables significant after Bonferroni adjustment for multiple testing are marked (*) Figure 1: Cardiopulmonary exercise test at laboratory for exercise testing University Hospitals Leuven Results Table 1: Patients characteristics compared with age and gender matched controls for patients with an open ASD and patients with a closed ASD. Patients with a closed ASD had higher BMI when compared to controls. R = Spearman’s correlation coefficient Conclusions Both patients with open and repaired ASD type secundum presented with impaired exercise capacity and lower peak oxygen pulse. Peak oxygen consumption correlated with self-reported physical functioning and role limitation in patients with open ASD. SF-36 appears to be sensitive to detect reductions in physical functioning in patients with an open ASD. M, Male; F, female; BMI, body mass index;BP, blood pressure References Gratz A, Hess J, Hager A. Self-estimatedphysicalfunctioningpoorlypredictsactualexercisecapacity in adolescents and adultswithcongenitalheartdisease. EurHeart J. 2009; 30:497-504 Hager A, Hess J. Comparison of healthrelatedquality of lifewithcardiopulmonaryexercisetesting in adolescents and adultswithcongenitalheartdisease. Heart. 2005; 91:517-520 Moons P, Van Deyk K, Marquet K, Raes E, De Bleser L, Budts W, De Geest S. Individualquality of life in adultswithcongenitalheartdisease: a paradigm shift. EurHeart J. 2005; 26:298-307