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Possible origins of yeast prion domains from polyQ/n tracts

Possible origins of yeast prion domains from polyQ/n tracts. Alexander Alexandrov , Michael Ter-Avanesyan. Amyloids and prions in yeast. Glutamine/Asparagine rich amyloidogenic sequences. Homogenous. Heterogenous. natural. NQGNNQQNYQ (50+). QQQQQQQQQ (35+). QQQYQQQQYQ (50+).

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Possible origins of yeast prion domains from polyQ/n tracts

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  1. Possible origins of yeast prion domains from polyQ/n tracts Alexander Alexandrov, Michael Ter-Avanesyan

  2. Amyloids and prions in yeast Glutamine/Asparagine rich amyloidogenic sequences Homogenous Heterogenous natural NQGNNQQNYQ (50+) QQQQQQQQQ (35+) QQQYQQQQYQ (50+) artificial NNNNNNNN Accumulation of mutations in polyQ

  3. Importance Prions – blessing or disease? Was there positive selection for prion properties? Emergence of prionogenic proteins may be a inevitable consequence of the existence of numerous proteins with polyQ and polyN in the proteome.

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