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Development and differentiation, example of “sticky” switching

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  1. Development and differentiation, example of “sticky” switching Brief Stimulus (Fertilization) Development continues with no additional stimulation How do the development circuits enable “sticky” switching?

  2. Like a microprocessor Sea Urchin Development Network: Davidson, et al., Science, 2002

  3. Quorum sensing Credit: Bonnie Bassler, et al., Princeton U.

  4. Quorum Sensing Circuit

  5. Microprocessor Electro- mechanical Processes Cell-based Biosensor Chemical and Biochemical Processes Synthetic biology?

  6. Band dector (of chemical concentrations) Credit: S. Basu, et al., Princeton U.

  7. Biochip for toxin detection Cells glow when detect toxins. Luminescence is detected by an integrated photosensor circuit. • Compounds Detected • Napthalene • TCE • Tolulene • Benzene • Xylene • Sensitivity: <50 ppb Cells Photodetector Chip Credit: M.L. Simpson, M. L., et al. , Oak Ridge National Lab

  8. Eukaryotes Prokaryotes

  9. Chromatin form depends on cell cycle phase

  10. Percentage of recognized pregnancies with trisomies (3 copies of a chromosome) From JF Crow, Nature Reviews Genetics, 2000