What can (many) sequences tell us? - PowerPoint PPT Presentation

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What can (many) sequences tell us?

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  1. What can (many) sequences tell us?

  2. Vriend’s first rule of sequence analysis If it is conserved, it is important

  3. Vriend’s second rule of sequence analysis If it is very conserved, it is very important

  4. Part of the big alignment

  5. NR2A2-HN4G NR2B3-RRXG NR2A5-HN4 d? NR2B1-RRXA NR2B2-RRXB NR3C1-GCR NR2A1-HNF4 NR3C4-ANDR NR3A1-ESTR NR2C2-TR4 NR3C3-PRGR NR2C1-TR2-11 NR0B1-DAX1 NR2E1-TLX NR3A2-ERBT NR0B2-SHP NR3C2-MCR NR2E3-PNR NR3B1-ERR1 NR6A1-GCNF NR3B2-ERR2 NR2F6-EAR2 NR5A1-SF1 NR2F2-ARP1 NR5A2-FTF NR2F1-COTF NR4A1-NGFI NR4A3-NOR1 NR1C1-PPAR NR4A2-NOT NR1C2-PPAS NR1H4-FAR NR1C3-PPAT NR1H3-LXR NR1D1-EAR1 NR1D2-BD73 NR1I1-VDR NR1F3-RORG NR1H2-NER NR1A2-THB1 NR1F1-ROR1 NR1I2-PXR NR1A1-THA1 NR1F2-RORB NR1B3-RRG1 NR1B1-RRA1 NR1B2-RRB2 NR1I4-CAR1-MOUSE- NR1I3-MB67 Nuclear receptor family

  6. CWPAASTFLGAACPW CWPASSNGSACPW CWPAASTFLGAACPW CWPASSNGSACPW CWPRASTNAAACPW CWPAASTFLGAACPW CWPASSNGSACPW CWPRASTNAAACPW CWPRASSYNAAACPW CWPAASTFLGAACPW CWPASSNGSACPW CWPRASTNAAACPW CWPRASSYNAAACPW CWPASSTFNGAACPW CWPAASTFLGAACPW 1 CWPASSN—-GSACPW 2 CWPAASTFLGAACPW 1 CWPRASTN-AAACPW 3 CWP-ASSN-GSACPW 2 CWPRAST-NAAACPW 3 CWPRASSYNAAACPW 4 CWPAASTFLGAACPW 1 CWPASSN—-GSACPW 2 CWPASS—-NGSACPW 2 CWPASSTFNGAACPW 5 CWPAASTFLGAACPW 1 CWPRAST-NAAACPW 3 CWPRASSYNAAACPW 4

  7. Final rule of sequence alignment Go back over the bioinformatics 1 course…