Who Needs Vitamin C? . “Vitamin C is unique…as its essentiality as a nutrient is restricted to only a limited number of exceptional species among phylogenetically higher animals. In other words, nearly all higher animals can synthesize vitamin C…”. 1991. Scurvy. R.I.P. Vitamin C.
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“Vitamin C is unique…as its essentiality as a nutrient is restricted to only a limited number of exceptional species among phylogenetically higher animals. In other words, nearly all higher animals can synthesize vitamin C…”
“…the most sudden and visible good effects were perceived from the use of the oranges and lemons; one of those who had taken them, being at the end of six days fit for duty.”
A treatise of the scurvy, 1753
1907 Scurvy occurs in guinea pigs.
1957 Scurvy due to lack of enzyme.
1913 Scurvy occurs in other primates.
1934 Vitamin C artificially synthesized.
1933 Vitamin C identified and described.
1933: Vitamin C identified and described.
1934: Vitamin C artificially synthesized.
1913: Scurvy occurs in other primates.
1957: Scurvy due to lack of enzyme.
1907: Scurvy occurs in guinea pigs.
D-GLUCOSEVitamin C Production
Prediction: If the ancestors of humans, other higher primates, and guinea pigs originally had the ability to synthesize vitamin C, then each of these species should carry evidence of this lost ability in their genes.
premature STOP codons
premature STOP codon
GULO-related sequence comparison from exon X
GULO-related sequence comparison from exon III