1 / 16

Epistasis

Epistasis. Definition. Epistasis is a form of gene interaction in which one gene masks the phenotypic expression of another. There are no new phenotypes produced by this type of gene interaction. Epistatic versus Hypostatic.

dineen
Download Presentation

Epistasis

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript


  1. Epistasis

  2. Definition • Epistasis is a form of gene interaction in which one gene masks the phenotypic expression of another. • There are no new phenotypes produced by this type of gene interaction.

  3. Epistatic versus Hypostatic • The alleles that are masking the effect are called epistatic alleles • The alleles whose effect is being masked are called the hypostatic alleles.

  4. How do we solve epistatic problems? • We are dealing with polygenic traits as in the previous section, however we now have one pair of alleles masking the other. • This means we will still be using dihybrid crosses!

  5. Recessive or Dominant? • Epistasis can be described as either recessive epistasis or dominant epistasis. • Let’s look at an example of recessive epistasis….

  6. Labrador Retrievers • Fur color in Labrador Retrievers is controlled by two separate genes. • Fur color is a polygenic trait! Gene 1: Represented by B : Controls color Gene 2: Represented by E : Controls expression of B

  7. Labrador Retrievers • If a Labrador retriever has a dominant B allele, they will have black fur. • If they have two recessive alleles (bb) they will have brown fur.

  8. Labrador Retrievers • If a retriever receives at least one dominant “E” allele, they will remain the color that the “B” allele coded for. • Either black of brown • However, if a dog receives a pair of homozygous recessive “e” alleles, they will be golden regardless of their “B” alleles!

  9. Labrador Retrievers • BBEE and BbEe --> Black retrievers • bbEE and bbEe --> Brown retrievers • BBee, Bbee, or bbee --> Golden retrievers

  10. Try this cross… • You have decided to cross your golden retriever (bbee) with the neighbor’s chocolate retriever (bbEe). What color pups will they have?

  11. bbee x bbEe • FOIL: be • FOIL: bE or be • Genotypes of F1 generation: bbEe and bbee • Pups phenotypes:Brown and golden

  12. Dominant Epistasis • Let’s have a look at dominant epistasis… • Squash fruit color is controlled by two genes. • Gene 1 is represented by a W • Gene 2 is represented by a G

  13. Squash Fruit Color • Genotypes and Phenotypes: • W-/G- white • W-/gg white • ww/G- green • ww/gg yellow

  14. Squash Fruit Color • Which allele is epistatic in squash color? • How do you know? The dominant W allele is epistasis Because every time a dominant W allele shows up in a squash genotype, the squash fruit color is white.

  15. Try this cross…. • Cross a green squash (wwGg) with a white squash (Wwgg). • What color are the offspring?

  16. Wwgg x wwGg • FOIL: Wg or wg • FOIL: wG or wg • F1 generation genotypes: • Phenotypes:

More Related