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Cell Signaling - PowerPoint PPT Presentation


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Cell Signaling. Tidbit Overview. Course: Introductory Cell Molecular Biology. Unit title: Cell Signaling – The Original Social Networking. Class enrollment: 25 – 250 freshman or sophomore Student experience: Near the end of the term. Within the signal transduction unit

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Presentation Transcript
slide2

Tidbit Overview

Course: Introductory Cell Molecular Biology.

Unit title: Cell Signaling – The Original Social Networking.

Class enrollment: 25 – 250 freshman or sophomore

Student experience: Near the end of the term. Within the signal transduction unit

Homework and pre-class assessment to encourage participation:

Review cell signaling (notes and previous class content) and turn in written responses to LOC/HOC questions.

slide3

Sensing the Rainbow: Demonstration of signal detection and transduction

  • Nose pinched
  • Chew skittle
  • Let go of nose
  • What happens?
slide4

Sensing the Rainbow: Demonstration of signal detection and transduction

  • Nose pinched
  • Chew skittle
  • Let go of nose
  • What happens?
activity and outcomes
Activity and Outcomes
  • Activity: Dramatize a signal transduction pathway
  • Outcome: The students will be able to model a hypothetical signal transduction pathway to elicit a specific cellular response
what we want you to know and do
What we want you to know and do
  • Evaluate the G protein coupled receptor pathway
  • Identify key components of cell signaling pathways
  • Design a skit to illustrate the mechanics of the pathway
  • Predict how the pathway would change under different conditions
slide8

Timing of Tidbit

Min Activity

0-2: Introduction and demonstration

2-7: In your NASI group evaluate your returned homework (total 8 groups)

7-21: Two groups merge, to plan performance (total 4 groups)

21-26: Combine 2 planning groups; perform/critique (total 2 groups)

slide9

5 Min:

  • In your NASI groups look at your returned homework handout.
  • Evaluate this piece of work using the following rubric:
slide10

13 Min:

  • Two groups merge (now 4 groups in total)
  • Create dramatization to illustrate pathway
  • Suggestion – divide the group into performers and a director
slide11

5 Min: Dramatime!

Again pair with another group

Within pair, one group performs, the other critiques (using Rubric provided) the performance

wild card 1 beta blocker examples inderal or lopressor
Wild Card 1Beta blocker – examples Inderal or Lopressor
  • Blocks the binding site for epinephrine on the beta-receptor
  • What is the effect on your signaling pathway?
wild card 2 caffeine

Wild Card 2: Caffeine

Inhibits the phosphodiesterase that breaks down cAMP.

How does this affect your signaling pathway?

wild card 3 anthrax
Wild Card 3 - Anthrax

One toxin in Anthrax (EF) - Increases cAMP levels

Another (LF) triggers the degradation of the kinase further downstream

student outcomes
Student Outcomes
  • Were you able to evaluate and construct a complete signaling pathway based on other students’ homework?
  • Were you able to create an accurate skit that showed you learned the pathway?
  • Did you see how altering the pathway affected signal transduction?
  • Did acting out this cellular process deepen your understanding of cell biology?
professor outcomes
Professor Outcomes
  • Did the students achieve the learning objective?
    • Modeling a hypothetical signal transduction pathway that elicited a cellular response?
  • Make notes in Teacher Diary of the successes and problems with executing the activity.