Myval THV Transcatheter Heart Valve by Meril Life

1. At the heart of life. At the heart of precision.

2. MyVal-1 Study Favourable Outcomes at 1-year * Device-related Mortality Incidence of Stroke New Permanent Pacemaker Low *MyVal-1 study, one year results presented by Dr. Ravinder Singh Rao at PCR Valves e-Course 2020

3. Myval THV: Designed for Precision in Outcomes Hybrid Honeycomb Cell Design Concept Cobalt alloy frame for high radial strength & radiopacity Open cells on upper half to ensure un-jailing of coronary ostia ≈ 53% Frame height 17-21 mm $ treatedbovinepericardium AntiCa tri-leaflet valve Closed cells on lower half for high radial strength ≈ 47% External PET skirting to plug microchannels & further reduce PVL Internal PET sealing cuff for minimizing PVL & puncture resistance Ø – 20 mm, 21.5 mm, 23 mm, 24.5 mm, 26 mm, 27.5 mm, 29 m m Ø – 30.5 mm , 32 mm XL Sizes Myval THV has been indigenously developed by Meril Life Sciences Pvt. Ltd. $ - Meril's proprietary anti-calcification treatment technologyAll AntiCa Myval THV sizes are CE approved

4. Myval THV: Unique Crimping Outcome Upon Crimping: V-shaped hinges on hexagonal frame fold, generating the dense bands on fluoroscopy Vertical connectors ‘|’ give rise to light bands Alternating V- folds & vertical connectors give Myval T H V a unique ‘ZebraCrossing’appearance on fluoroscopy for ease of positioning th Dense Band 4 rd Light Band 3 Aortic End rd Dense Band 3 Commissure Cells 53% Commissure nd Light Band 2 Open nd Dense Band 2 Cells 47% st Light Band 1 Closed st Dense Band 1 Ventricular End Myval THV is recommended to be crimped over Navigator THV Balloon Delivery System prior to insertion within introducer sheath Illustrations are artist's representation and should not be considered as engineering drawings or photographs

5. Myval THV: Precise Placement Technique Schematic of Myval THV - Ideal Landing Zone Minimum foot-print in LV (70% Aortic : 30% Ventricular) Minimal movement across the annulus to locate the THV landing zone Proximal Balloon Marker Landing Zone 2 nd Dense band Mid Balloon Marker 2 nd Light Band Annular Plane nd Dense Band 1 st 2 st Light Band 1 Dense Band Distal Balloon Marker Upon Crimping Alternating V-folds & vertical connectors give Myval THV a unique appearance on fluoroscopy for ease of positioning Distal End Towards Ventricle Elimination of THV frame parallax promptly ensures visualisation of characteristic dark-light bands Fluoroscopic images have been dramatized & and may not be in 1:1 ratio Illustrations are artist's representation and should not be considered as engineering drawings or photographs

6. Myval THV: Ground Zero Deployment Shallow deployment of Myval THV with least engagement within LVOT is possible Optimal orthotopic anchorage of Myval THV with marginal LVOT foot-print without risk of THV migration Minimal infra-annular depth ≤3.50mm avoids conduction system interference (thus minimizing the need o f new permanent pacemaker dependency) Largest circumscribable diameter in Open Cell (for all Myval THV Diameters 20mm to 32mm) Cells 53% Open 6 mm Cells 47% Closed Myval THV infra-annular depth ≤3.50mm based on THV Ø Image ref : Tawara et al. JACC CardioVascular Interventions 2008; 1:310-316. Angio image courtesy Dr. Luigi Salemme, Montevergine Hospital Napoili, Italy.

7. Myval THV: Detailed Sizing Guide 2 3D Annular area mm 270 280 290 300 310 314 320 330 340 350 360 3D area-derived diameter mm 18.5 18.9 19.2 19.5 19.9 20.0 20.2 20.5 20.8 21.1 21.4 20 mm 16.4% 12.2% 8.3% 4.7% 1.3% 0.1% -1.8% -4.8% -7.6% -10.2% -12.7% % Annular area over/under 21.5 mm 34.5% 29.7% 25.2% 21.0% 17.1% 16% 13% 10% 7% 4% 0.8% 23 mm 53.9% 48.4% 43.3% 38.5% 34.0% 32.3% 29.8% 25.9% 22.2% 18.7% 15.4% 2 3D Annular area mm 370 380 390 400 410 415 420 430 440 450 460 470 3D area-derived diameter mm 21.7 22.0 22.3 22.6 22.8 23.0 23.1 23.4 23.7 23.9 24.2 24.5 12.3% 9.3% 6.5% 3.9% 1.3% 0.1% -1.1% -3.4% -5.6% -7.7% -9.7% -11.6% 23 mm % Annular area over/under 27.4% 24.1% 20.9% 17.9% 15.0% 13.6% 12.2% 9.6% 7.1% 4.8% 2.5% 0.3% 24.5 mm 43.5% 39.7% 36.1% 32.7% 29.5% 27.9% 26.4% 23.5% 20.7% 18.0% 15.4% 13.0% 26 mm 2 3D Annular area mm 480 490 500 510 520 530 540 550 560 570 580 590 24.7 25.0 25.2 25.5 25.7 26.0 26.2 26.5 26.7 26.9 27.2 27.4 3D area-derived diameter mm 10.6% 8.4% 6.2% 4.1% 2.1% 0.2% -1.7% -3.5% -5.2% -6.9% -8.5% -10.0% 26 mm % Annular area over/under 23.7% 21.2% 18.8% 16.5% 14.2% 12.1% 10.0% 8.0% 6.1% 4.2% 2.4% 0.7% 27.5 mm 37.6% 34.8% 32.1% 29.5% 27.0% 24.6% 22.3% 20.1% 17.9% 15.9% 13.9% 12.0% 29 mm 2 3D Annular area mm 600 610 620 630 640 650 660 670 680 690 700 710 27.6 27.9 28.1 28.3 28.5 28.8 29.0 29.2 29.4 29.6 29.9 30.1 3D area-derived diameter mm 10.1% 8.3% 6.5% 4.8% 3.2% 1.6% 0.1% -1.4% -2.9% -4.3% -5.6% -7.0% 29 mm % Annular area over/under 30.5 mm 21.8% 19.8% 17.8% 16.0% 14.2% 12.4% 10.7% 9.0% 7.4% 5.9% 4.4% 2.9% 32 mm 34.0% 31.8% 29.7% 27.7% 25.7% 23.7% 21.9% 20.0% 18.3% 16.6% 14.9% 13.3% 2 3D Annular area mm 720 730 740 750 760 770 416 790 800 810 820 830 840 3D area-derived diameter mm 30.3 30.5 30.7 30.9 31.1 31.3 23.0 31.7 31.9 32.1 32.3 32.5 32.7 11.7% 10.2% 8.7% 7.2% 5.8% 4.4% 93.3% 1.8% 0.5% -0.7% -1.9% -3.1% -4.3% % Annular area over/under 32 mm Area-derived diameter based on MSCT cross-sectional measurements

8. Myval THV: Size Matrix 2 2 2 2 Area 314 mm Area 363 mm Area 415 mm Area 471 mm Myval THV Size Matrix & Technical Specifications 17.35 mm 18.35 mm 17.85 mm 18.75 mm 20 mm 21.5 mm 23 mm 24.5 mm Perimeter 62.83 mm 67.54 mm 72.26 mm 76.97 mm Native annulus area 2 2 2 2 270 - 330 mm 314 - 380 mm 360 - 440 mm 410 - 500 mm Area-derived diameter 18.5 - 20.5 mm 20 - 22 mm 21.4 - 23.7 mm 22.8 - 25.2 mm Native annulus size by TEE 16 - 19 mm 17.5 - 20.5 mm 18 - 22 mm 19.5 - 23.5 mm

9. All Myval THV Diameters (20 mm to 32 mm) are Compatible with 14Fr Python - Introducer Sheath Myval THV XL Sizes 2 2 2 2 2 Area 531 mm Area 594 mm Area 661 mm Area 731 mm Area 804 mm 20.35 mm 21.14 mm 18.85 mm 19.25 mm 20.9 mm 26 mm 27.5 mm 29 mm 30.5 mm 32 mm 81.68 mm 86.39 mm 91.11 mm 95.82 mm 100.53 mm 2 2 2 2 2 460 - 560 mm 510 - 630 mm 570 - 700 mm 630 - 770 mm 700 - 840 mm 24.2 - 26.7 mm 25.5 - 28.3 mm 26.9 - 29.9 mm 28.3 - 31.3 mm 29.9 - 32.7 mm 21 - 25 mm 22.5 - 26.5 mm 24 - 28 mm 25.5 - 29.5 mm 27 - 31 mm

10. Myval THV: Post Deployment Dimensions Chart Myval THV Diameters (Ø) 20 mm 21.5 mm 23 mm Cells 53% Total frame height Open 17.35 mm 18.35 mm 17.85 mm Open cell height (53%) 9.20 mm 9.73 mm 9.46 mm Cells 47% Closed Closed cell height (47%) 8.15 mm 8.62 mm 8.39 mm * 3.05 mm 3.20 mm 2.85 mm Infra-annular depth Supra-annular height of closed cells 5.10 mm 5.42 mm 5.54 mm 6 mm Recommendation for coronary protection 10 mm 10 mm 10 mm   A balloon occlusion test may be considered to assess the propensity for coronary occlusion Balloon diameter approximated to shortest axis of CT-derived annular diameter to be considered Largest circumscribable diameter in Open Cell * Infra-annular depth may depend on final landing zone position prior to valve deployment. The values mentioned are indicative range. (for all Myval THV Diameters 20mm to 32mm)

11. Myval THV XL Sizes 24.5 mm 26 mm 27.5 mm 29 mm 30.5 mm 32 mm 18.75 mm 18.85 mm 19.25 mm 20.35 mm 20.90 mm 21.14 mm 9.94 mm 9.99 mm 10.20 mm 10.79 mm 11.08 mm 11.21 mm 8.81 mm 8.86 mm 9.05 mm 9.56 mm 9.82 mm 9.94 mm 2.95 mm 3.05 mm 3.15 mm 3.35 mm 3.45 mm 3.55 mm 5.86 mm 5.81 mm 5.90 mm 6.21 mm 6.37 mm 6.39 mm 10 mm 10 mm 10 mm 10 mm 10 mm 10 mm •Consider protection of coronary arteries with a DES especially if height of coronary ostium is <10 mm from the annular plane and i n conjunction with sinus of valsalva dimensions i.e. height & diameters

12. Navigator THV Delivery System Delivering TAVI Made Easy Myval THV is recommended to be crimped over Navigator THV Delivery System prior to insertion w ithi n introducer sheath The crimped valve with delivery system is then loaded through 14Fr Python – Introducer Sheath Proximal Stopper Crimped Valve Distal Stopper Navigator with Myval THV Navigator delivery system has a set of proximal and distal stoppers which ensure that valve crimping is precis e and snug Visual confirmation of crimped valve can be ensured before entering the sheath to avoid any crimping errors/defects The stoppers prevent inadvertent migration of the valve & ensure there is no risk of valve dislodgement (embolization) during entry through the sheath or while negotiating the loaded delivery system across the aorta Myval THV direct crimping on the balloon makes TAVI delivery simple, intuitive and eliminates unwarranted procedural steps

13. Navigator THV Delivery System Characteristic Balloon Expansion Navigator balloon with dual expansion ports at each end ensures rapid, simultaneous, controlled expansion (dog-boning) of distal and proximal ends This typical dog bone pattern of inflation steadies the valve during expansion phase, ensuring i t s precise annular position and deployment without any risk of valve migration Rapid balloon inflation, using an inflation device is possible with controlled palm thrust Rapid balloon deflation within 3-5 sec ensures procedural safety and compliance

14. Navigator THV Delivery System 0.035” guide wire Proximal Shaft with Rotatory Handle for Hi-Flexion Usable catheter length 120 cm 14 Fr 29 mm 26 mm 27.5 mm Navigator Balloon Ø 23 mm 20 mm 21.5 mm 24.5 mm 32 mm 30.5 mm Balloon Length 30 mm 35 mm 6 atm Balloon RBP Volume of 75:25 Saline: Contrast to achieve stated balloon diameter 20 ml 23 ml 28 ml 32 ml 36 ml 12 ml 15 ml 18 ml 40 ml Navigator – THV Delivery System has been indigenously developed by Meril Life Sciences Pvt. Ltd.

15. Navigator THV Delivery System: Proximal Assembly Clock-wise rotation to achieve distal end flexion 0.035” guide wire exit port Proximal shaft with rotatory handle for Hi-Flexion Un-deflected catheter position (straight) Maximum deflection catheter position Balloon inflation port Hi-flexion feature ensures tracking the THV delivery system via inner aortic arch curve thereby minimizing the risk of contralateral wall scraping Caution: Always remember to fully un-flex the Navigator system while withdrawing

16. 14Fr Python – Introducer Sheath Compatible with all Myval THV Diameters (20 mm to 32 mm) Sheath expands momentarily like a python swallowing its prey Conveniently allows passage of crimped Myval THV System 14Fr Entry Profile, Allows Atraumatic Percutaneous Access High convenience for full retrievability of an un-deployed Myval THV System Proximal Port with Hemostatic valves Counter opposing suturing eyelets RO distal tip Lubricious, hydrophilic shaft coating 30 cm usable length Seamless transition from dilator to distal tip Dilator with locking threads Convenient side port with 3-way Common Femoral Artery* Ø (mm) > _ 5.50 mm > _ 6.00 mm > _ 6.50 mm Myval THV Ø (mm) Two separate, calibrated loading tubes ensure temporary opening of hemostatic valves in proximal port allowing smooth passage of crimped Myval THV System 20 mm, 21.5 mm, 23 mm, 24.5 mm 26 mm, 27.5 mm, 29 mm 30.5 mm, 32 mm 2+ *CFA Ø must be MSCT derived. Excluding circumferential Ca Python - Introducer Sheath has been indigenously developed by Meril Life Sciences Pvt. Ltd.

17. Mammoth - OTW Balloon Catheter Pre-dilatation is entirely operator’s discretion and not mandatory 0.035” guide wire compatibility Soft, atraumatic nose cone 2 RO markers exclusive of balloon length Non-compliant balloon 9 Fr 14 mm 16 mm 18 mm 20 mm 23 mm 25 mm 28 mm 30 mm Mammoth Balloon Ø 130 cm usable shaft length 40 mm Balloon length 8 atm 6 atm Balloon RBP Volume of 75:25 saline: contrast toachieve stated diameter Over-the-wire system 10 ml 13 ml 34 ml 42 ml 8 ml 16 ml 23 ml 25 ml Mammoth – OTW Balloon Catheter has been indigenously developed by Meril Life Sciences Pvt. Ltd.

18. Pre-Dilatation & Balloon Sizing Rationale Balloon diameter approximated to shortest axis of annular diameter measured on MSCT to be considered in order to - Ensure controlled crossing of THV across the diseased, narrowed annulus (AVA)(prevent abrupt jumping into LV) Minimize unwarranted risk of AR due to pre-dilatation Reduce propensity for iatrogenic damage to the conduction system Simulate expansion behavior of the diseased native leaflets Assess potential risk of ostial jailing and estimate coronary perfusion Dmin Dmax AoV Annulus Cross-sectional View

19. Myval THV: Global Clinical Program ~4000 Patients 1 MyVal-1 (n=100) Meril Initiated Single arm Prospective FIH study 29 Indian sites STS ≥ 4 - ≤ 15 100 pt. 1-year follow-up presented by Dr. Ravinder Singh Rao at PCR Valves e-Course 2020 LANDMARK Trial 2 3 Myval European Study (n=200) Compare-TAVI (n=1,062) 4 (n=768) 5 6 (n=125) Myval-Global (n= 2,000) Myval-China 2MerilInitiated 3InvestigatorInitiated 4MerilInitiated 5MerilInitiated 6MerilInitiated RCT – 1:1 Myval : Sapien 3 RCT – 2:1:1 Myval : Sapien : Evolut THV series Single arm Single arm Single arm Retrospective EU Registry 20 EU sites Real world STS Data collection in progress 30-day f/up est. @ PCR-LV 2021 Prospective study 10 Nordic + EU sites Real world STS Enrollment has started 1-year f/up est. @ EuroPCR 2023 Prospective study 50+ EU/ANZ sites Real world STS Currently enrolling 1-year f/up est. @ EuroPCR 2023 Prospective study 100 Global sites Real world STS Under planning First patient rst visit est. @ QIV 2021 Prospective study 10 China sites Real world STS Pre-study activities initiated First patient rst visit est.@ QIV 2022

20. MyVal-1: Study Design A prospective, multicentre, single-arm, open-label study of Myval THV i n the treatment of severe symptomatic native aortic valve stenosis. Total number of patients: 100 Device Sizes – 20, 21.5, 23, 24.5, 26, 27.5 and 29 mm CLINICAL FOLLOW-UP N = 100 30-day 6-month 1-year* 2-5 years Follow-up Clinical Follow-up Echocardiographic Follow-up Quality of Life Measurement Dr. Ashok Seth - Principal Investigator New Delhi, India Dr. Samin Sharma - Chairman New York, USA Dr. Ravinder Singh Rao - Co-ordinating PI Jaipur, India Dr. P. K. Goel - Scientific Advisor Lucknow, India Dr. Praveen Chandra - Co-ordinating PI New Delhi, India Study Investigators: Samin Sharma, Ravinder Singh Rao, John Jose, Praveen Chandra, Pravin K. Goel, G. Sengottuvelu, Prashant Bharadwaj, C. N. Manjunath, P. C. Rath, Rajiv Chandrasekharan Nair, Rajpal Abhaichand, Ajit Mullasari, V. K. Ajith Kumar, Ajaykumar U. Mahajan, Ganesh K u m a r , Jaspal Singh Arneja, Keyur Parikh, R. K. Jain, S. M. Sharma, B. B. Chanana, Jagdish Parikh, M. S. Hiremath, Rishi Sethi, Rony Mathew Kadavil, R. R. Mantri, Sanjay Mehrotra, Tarlochan Singh Kler, T. R. Murlidharan, Vijay Trehan, Ashok Seth MyVal-1 study, one year results presented by Dr. Ravinder Singh Rao at PCR Valves e-Course 2020 MyVal-1 Study (CTRI/2016/11/007512) Sharma SK, et.al. First-in-human evaluation of a novel balloon-expandable transcatheter heart valve in patients with severe symptomatic native aortic stenosis: the MyVal-1 study. EuroIntervention. 2020 Aug 28;16(5):421-9. PMID: 31566572. doi: 10.4244/EIJ-D-19-00413 Erratum for: EuroIntervention. 2020 Aug 28;16(5):421-429. PMID: 32855114. doi: 10.4244/EIJ-D-19-00413C

21. MyVal-1: Baseline Characteristics Patient History Based on the annular size, a bioprosthetic valve of specific size was decided for each patient Average Age (years) 73.51 ± 7.49 47 Mean STS 5.12 ± 1.64 Number of patients History of Coronary Artery Bypass Graft surgery 17% 27 History of Previous PCI 13% History of Previous Aortic Valvuloplasty 1% 11 10 History of Cerebro-Vascular Events 3% 2 2 1 20 21.5 23 24.5 26 27.5 29 Peripheral Vascular Disease 3% Myval THV diameters (Ø) mm When novel intermediate sizes of the transcatheter heart valves were introduced, recruitment of only 10% of patients was remaining (of 10 patients, 5 patients were implanted with the intermediate-size study device) 23 mm transcatheter heart valve was implanted in 47% of the patient population- reflective of the Indian aortic annulus anatomy

22. MyVal-1: Cumulative Clinical Outcomes up to 1-Year Follow-up 6-Month Follow-Up (n=100) 12-Month Follow-Up (n=100) Post-procedure (n=100) 1-Month Follow-Up (n=100) # Clinical Events Survival 98% 97% 91% 87% All-cause Mortality 2% 3% 9% 13% All Stroke 1% 2% 2% 2% Disabling 0% 1% 1% 1% Non-disabling 1% 1% 1% 1% Acute Renal Failure 2% 2% 2% 2% Life-threatening or disabling bleeding 1% 1% 1% 1% Endocarditis 0% 0% 1% 1% Myocardial Infarction 0% 0% 0% 1% Vascular Complications 3% 3% 3% 3% Repeat Hospitalization NA 8% 11% 17% New Permanent Pacemaker 2%* 2% 2% 2% *One patient had RBBB pre-procedure #Kappetein AP, Head SJ, Généreux P, et al. Updated standardized endpoint definitions for transcatheter aortic valve implantation: the Valve Academic Research Consortium-2 consensus document. Eur Heart J. 2012;33:2403-2418.

23. MyVal-1: Marked Improvement in Quality of Life Parameters Kansas City Cardiomyopathy Questionnaire Score Six-minute walk test 278.5 300 60 51.5 49.9 48.1 247.5 50 250 233.2 172.1 40 200 37.0 Distance (m) 30 150 Score 20 100 10 50 0 0 Baseline 1-month 6-month 12-month Baseline 1-month 6-month 12-month There was significant improvement in six-minute walk test and Kansas City Cardiomyopathy Questionnaire score from baseline to 12 months

24. MyVal-1: Study Conclusion In 100 intermediate to high-risk patients of MyVal-1 study, the next-generation balloon-expandable transcatheter heart valve system demonstrated favourable clinical and haemodynamic outcomes at 12-month follow-up 87% survival and low incidence of all stroke (2%) Low rate (2%) of new permanent pacemaker implantation High procedural success that can be attributed to precise orthotopic valve positioning In real-world global experience of 2500+ cases; Myval THV has been consistently demonstrating high procedural success and clinical performance Unique hybrid honey-comb geometry for precise positioning and orthotopic deployment Preserve THV geometry & respect patient’s anatomy. Large size matrix : Conventional Ø 20, 23, 26, 29 mm, Intermediate Ø 21.5, 24.5, 27.5 mm & XL Ø 30.5, 32 mm Direct THV crimping on Navigator balloon makes TAVI delivery simple, intuitive and eliminates unwarranted procedural steps Compatibility of novel 14Fr Python Introducer Sheath for all Myval THV Øs (20-32 mm); with high convenience of full retrievability of an un-deployed Myval THV system

25. LANDMARK Trial – 50+ Sites EU+ANZ Total Population N = 768 Contemporary THV Series Sapien (50%) & Evolut (50%) N = 384 Myval THV Series N = 384 1 : 1 Randomization Myval vs Sapien N = 576 Myval vs Evolut N = 576 2 : 1 allocation 2 : 1 allocation 2 : 1 allocation Myval N = 384 Sapien N = 192 Myval N = 384 Evolut N = 192 Primary Endpoint – 30 Days All cause mortality | All stroke | Life-threatening bleeding | Vascular complications Acute kidney injury | Paravalvular leak | New permanent pacemakers ECG/Echo Follow-up Video Densitometry Clinical Follow-up Baseline|Post Procedure| 30 D | 1 Y | 3 Y | 5 Y Post Procedure Upto 10 years Currently enrolling

26. Myval - THV Navigator - THV Delivery System Python - Introducer Sheath Mammoth - OTW Balloon Catheter

27. Myval THV System and Components - Ordering Information Myval - THV 29.0 mm 30.5 mm 32.0 mm MVL320 MVL305 Navigator - THV Delivery System 27.5 x 35 mm 29.0 x 35mm 30.5 x 35 mm 32.0 x 35 mm NVT27535 NVT29035 NVT32035 NVT30535 Mammoth - OTW Balloon Catheter 14.0 x 40 mm 16.0 x 40 mm 18.0 x 40 mm 20.0 x 40 mm 23.0 x 40 mm 25.0 x 40 mm 28.0 x 40 mm 30.0 x 40 mm MTV3040 MTV1440 MTV2840 Python - Introducer Sheath PHT14 Val-de-Crimp - Heart Valve Crimping Tool VLDC Myval, Navigator, Python, Mammoth & Val-de-crimp are registered trademarks of Meril Life Sciences Pvt. Ltd. These products are intended for use by or under the direction of a trained healthcare practitioner only Only quali ed medical experts can give you information regarding your individual treatment. Prior to use, refer the instructions for use/IFU. Data on le at Meril Life Sciences Pvt. Ltd. Illustrations are artist's representation and should not be considered as engineering drawings or photographs. Please check the regulatory approval status of Myval THV in your country Myval, Navigator, Python, Mammoth & Val-de-crimp are not approved and not available for sale in USA. Myval, Navigator, Python, Mammoth & Val-de-crimp are not available for sale in France. Myval THV is not available for sale in Germany

28. Check availability of Myval THV in your country Meril’s Global Presence Meril UK Pvt Ltd C/O Crowe U.K LLP, 2nd Floor, 55 Ludgate Hill, London, EC4m 7JW United Kingdom T: +447854524616 Meril Tibbi Cihazlar Meril Tıbbi Cihazlar İmalat ve Ticaret A.Ş.İçerenköy Mah. Çetinkaya Sok. Prestij Plaza No:28 Kat:4 Ataşehir, 34752 İstanbul, Turkey T: +90 216 641 44 24 F: +90 216 641 44 25 Meril Medical LLC. Nauchnyi Proezd 19, Moscow , Russia – 117 246. Office - +7 495 772 7643 Manufacturer Meril Life Sciences Pvt. Ltd. Survey No. 135/139, Bilakhia House, Muktanand Marg, Chala, Vapi 396 191 Gujarat, India T: +91 260 240 8000 Meril GmbH. Bornheimer Strasse 135-137, D- 53119 Bonn. Germany T: +49 228 7100 4000 F: +49 228 7100 4001 Meril China Co. Ltd. Room 2301B, 23F, Lixin Plaza, No 90, South Hubin Road, Xiamen, China T: 0086-592-5368505 F: 0086-592-5368519 Meril Life Sciences Pvt. Ltd. 301, A - Wing, Business Square, Chakala, Andheri Kurla Road, Andheri East, Mumbai - 400 093 India T: + 91 22 39350700 E: askinfo@merillife.com Meril, Inc. 2436 Emrick Boulevard, Bethlehem, PA - 18020 USA T: + 610 500 2080 F: + 610 317 1672 Meril SA Pty Ltd 102, 104, S101 and S102, Boulevard West Office Park, 142 Western Service Road, Erf 813 Woodmead Extension 17 Sandton, Johannesburg – 2191 South Africa T: +27 11 465-2049 F: +27 86 471 7941 EU Representative. Obelis S.A.Bd, General Wahis 53, 1030, Brussels, Belgium T : +32 2 732 5954 F : +32 2 732 6003 E mail@obelis.net Meril South America Doc Med LTDA Al. dos Tupiniquins, 1079 - Cep: 04077-003 - Moema, Sao Paulo, Brazil T: +55 11 3624 5935 F: +55 11 3624 5936

29. MVL/BROCHURE/005/MLS/20210428/GLOBAL