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GLYCOGEN BREAKDOWN AND SYNTHESIS ARE RECIPROCALLY REGULATED

GLYCOGEN BREAKDOWN AND SYNTHESIS ARE RECIPROCALLY REGULATED. Glycogen phosphorylase muscle liver Allosteric inactive “b” active “a” Regulation AMP: T to R glucose: R to T Covalent epinephrine glucagon (PKA) Regulation through PKA, Ca epinephrine (beta, alpha adr.)

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GLYCOGEN BREAKDOWN AND SYNTHESIS ARE RECIPROCALLY REGULATED

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  1. GLYCOGEN BREAKDOWN AND SYNTHESIS ARE RECIPROCALLY REGULATED

  2. Glycogen phosphorylase • muscle liver • Allosteric inactive “b” active “a” • Regulation AMP: T to R glucose: R to T • Covalent epinephrine glucagon (PKA) • Regulation through PKA, Ca epinephrine (beta, alpha adr.) • Inactivation of glycogen breakdown • GTPase • Phosphodiesterase • 3. Protein phosphatase 1 (PP1)

  3. Glikogén foszforiláz • izom máj • Alloszterikus inaktív „b” aktív „a” • szabályozás AMP: T-ből R glukóz: R-ből T • Kovalens epinefrin glukagon (PKA) • szabályozás (PKA, Ca) epinefrin • Glikogén-lebontás inaktiválása • GTPáz • Foszfodiészteráz • 3. Protein foszfatáz 1 (PP1)

  4. Substrates of PKA glycogen phosphorylase kinase (beta, alpha subunits) glycogen synthase PP1: Rgl and inhibitor subunit Substrates of PP1 glycogen phosphorylase kinase glycogen phosphorylase glycogen synthase (later)

  5. PKA szubsztrátjai glikogén foszforiláz kináz glikogén szintáz PP1 (Rgl és inhibitor alegység) PP1 szubsztrátjai glikogén foszforiláz kináz glikogén foszforiláz glikogén szintáz (később)

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