Lecture: 1. Immunology (elective) MLIM-101. Prepared by: Dr. Mohamed S. Abdel- Latif. INNATE ( NON-SPECIFIC ) IMMUNITY. Learning Outcome:. At this time you should know the following: 1. Differences between the non-specific and specific immune functions.
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At this time you should know the following:
1. Differences between the non-specific and specific immune functions.
2. Humoral components of the non-specific immune system and their action.
3. Cellular components of the non-specific immune function and their action.
4. Pathways of intracellular killing of bacteria by phagocytes and their characteristic features.
5. Effect of humoral components such as interferon, TNF, IL-2, complement etc. on cellular components of the non-specific immune system.
Cells of the Immune System
complement, interferon, TNF etc.
T cells; other effectors cells
Components of the Immune System
flushing, fatty acids
Peristalsis, low pH
bile salts, fatty acids
Effector mechanisms in Innate Immunity -1
Effector mechanisms in Innate Immunity -2
mucus, saliva, tears
phagocytosis and intracellular killing
K, NK & LAK cells
direct and antibody dependent cytolysis
Effector mechanisms in Innate Immunity -3
Serum and other serous fluids
antiviral proteins phagocyte activation
opsonization, enhanced phagocytosis, inflammation
Fibronectin & complement
azurophilic; characteristic of young neutrophils;
specific for mature neutrophils
contain cationic proteins, lysozyme, defensins, proteases and
contain lysozyme, NADPH oxidase, lactoferrinand B12-binding protein
Cationic proteins (cathepsin)
Damage to microbial membranes
Hydrolyses mucopeptides in the cell wall
Deprives pathogens of iron
Hydrolytic enzymes (proteases)
Digests killed organisms
As a part of the semester activity, group of students is selected every week to prepare a short seminar about his/her point of interest in one of the lecture topics. That to be discussed and evaluated during the next lecture.