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SPIRiT Kickoff Meeting. TIES Overview. Associate Professor, Department of Biomedical Informatics, University of Pittsburgh, School of Medicine crowleyrs@upmc.edu. Rebecca Crowley. Outline. What is caTIES ? What is TIES? History System (with demonstration) Evaluation Deployment

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spirit kickoff meeting

SPIRiT Kickoff Meeting

TIES Overview

Associate Professor,

Department of Biomedical Informatics,

University of Pittsburgh, School of Medicine

crowleyrs@upmc.edu

Rebecca Crowley

outline
Outline
  • What is caTIES? What is TIES?
  • History
  • System (with demonstration)
  • Evaluation
  • Deployment
    • Status Report at University of Pittsburgh
    • Other sites
  • Institutional Support and User Community
  • Work towards understanding requirements for a collaborative tissue network
what is caties
What is caTIES?
  • An NCI and CTSI funded research project
  • An open-source application for creating large repositories of highly processed, highly indexed, concept-coded, de-identified clinical documents
  • Retrieval of paraffin-embedded remainder tissue
  • Built on the GATE architecture
  • De-identification component typically de-ID but others are possible
  • Utilizes NCI vocabularies and MMTx (as well as NegEx and other components developed at Pittsburgh)
  • User Interface developed with HCI methods
  • Honest Broker paradigm
  • Grid communications (Globus) and Security Infrastructure (GSI, Dorian) for communication among nodes
what is ties
What is TIES?
  • Deployed UPMC-approved system for retrieving data and identifying and ordering tissue using surgical pathology clinical reports
  • Provides access to 1.7 million de-identified pathology reports, across all UPMC hospitals, from 1995-present, updated weekly and automatically from clinical systems
  • Close working relationship with Health Sciences Tissue Bank and Honest Broker human systems throughout University/UPMC
  • IT support, Training, Marketing activities
  • Currently has 100 users and 14 active protocols
history 1
History - 1
  • 2001 - 2006 Shared Pathology Informatics Network
    • NCI Sponsored U01 (Collaborative Consortium)
      • Harvard, UCLA, Regenstreif, Pittsburgh
    • NLP tools, ideas, first demonstration of data-sharing
  • 2005 - 2008 caBIG
    • Large multi-CC contract/community developing architecture + open source, interoperable systems for cancer research community
    • caTIES code base
    • Security Architecture
    • Grid Communications
    • User Interface
    • Version 1 and 2
    • Four institutions sharing some data, IRB protocol Penn-Pitt
history 2
History - 2
  • 2006 – 2011

University of Pittsburgh CTSA Project (ongoing)

    • Deployed at University of Pittsburgh
    • Worked with Tissue Bank
    • Set up honest brokers
    • Policies and Processes
    • IRB issues
    • caTIES v3
  • 2009 – 2014

caTIES NCI funded project (ongoing)

    • More autonomy
    • Stable, consistent release cycle
    • User community
    • New features
deployment at university of pittsburgh
Deployment at University of Pittsburgh
  • Currently 100 users and 14 active protocols
  • Marketing through end-user lunches and other events (8 workshops – 113 total participants)
  • IT Support through ISD
  • Website for account requests
    • http://ties.upmc.com/
  • Training of End-Users
  • User manual and Videos
caties deployments
caTIES Deployments

Since January 2010…

  • 878 downloads
  • 200+ forum posts
  • 3,000 unique visitors to caTIES website
  • 2,000 pageviews/month on Sourceforge
  • 25 requests for caTIES demo accounts
resources for deploying institutions
Resources for Deploying Institutions
  • FTE Estimates
  • Sample Implementation Plan
  • Web Resources
  • Policies and Processes
  • Pitt/Penn IRB Submission
  • Training Materials
  • Marketing Materials
  • caTIES Office Hours after each release
user community
User Community
  • Yearly caTIES user meeting
  • caTIESSourceForge site
    • http://sourceforge.net/projects/caties/
    • User forums and listservs
    • Bug reports and feature requests
  • caTIES project website
    • http://caties.cabig.upmc.edu/
    • Details and support for implementation
developing a collaborative network
Developing a Collaborative Network
  • Many players (caBIG, iDASH, NCBCs etc) make this a moving target
  • Great deal of work, needed to develop network, was done as part of caBIG Security Project (Manion, Robbins, Weems, Crowley, Whitney)
  • Foundation of work by Becich et al in Tissue Sharing
  • Policies for internal operation AS WELL AS multi-institutional use of the system
  • Trust Agreement, Concept of Operations, Requirements for Governing Body, etc.
  • SPIRiT is a different animal and probably MUCH easier because entry does not need to be open-ended.
challenges
Challenges
  • Governance
  • Trust Fabric
  • IRB issues (especially training modules)
  • De-identification and HIPAA
  • Auditing and Risk Management
  • ‘Real’ deployments and ‘Real’ use cases
  • Size and scope, present and future
  • Funding this effort