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Sugar Furr Acc 142056 Enzootic Nasal Adenocarcinoma of Small Ruminants

Sugar Furr Acc 142056 Enzootic Nasal Adenocarcinoma of Small Ruminants. Trisha Oura February 28, 2011. Sugar Furr. < 2yo F Suffolk Sheep Unilateral nasal discharge Swelling on head (left dorsal) Fluctuant, “reducible”. Radiographs. Ultrasound. Echogenic fluid (aspirated).

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Sugar Furr Acc 142056 Enzootic Nasal Adenocarcinoma of Small Ruminants

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  1. Sugar FurrAcc 142056Enzootic Nasal Adenocarcinomaof Small Ruminants Trisha Oura February 28, 2011

  2. Sugar Furr • < 2yo F Suffolk Sheep • Unilateral nasal discharge • Swelling on head (left dorsal) • Fluctuant, “reducible”

  3. Radiographs

  4. Ultrasound Echogenic fluid (aspirated) • Left nasal mass with frontal sinus obstruction or extension • DDX: cyst, hematoma, abscess, granuloma, neoplasia Minimally vascular, echogenic mass

  5. Neoplasia • Enzootic Nasal Adenocarcinoma of Small Ruminants • Rare (few case reports/case series in literature) • Sheep > goats • Young (e.g. 2-4yo), M=F • Upper respiratory signs (stridor, mouth breath), nasal discharge, head shaking, sneezing • Facial asymmetry, exophthalmos • Occasionally with concurrent inflammatory polyps in nasal cavity • Can have concurrent pneumonia • DDX: Oestrusovismyiasis

  6. Enzootic Nasal Adenocarcinoma (ENA)aka: infectious adenopapillomatosis, infectious adenopapilloma, infectious adenocarcinoma • Bilateral or unilateral • Can invade sinuses/adjacent bony structures • Usually arises from ethmoid mucosa • Rarely metastasize • Death due to anorexia, weight loss • Retroviral etiology • Similar to Jaagsiekte virus • ovine pulmonary carcinoma • Both are contagious tumors of respiratory epithelium, low grade malignancy

  7. ENA • Transmission: • Experimental intranasal innoculation • Prevalence: • US, Canada, Europe (Spain, Italy), Japan, China, India, Africa • No breed predisposition • Cases can be clustered in certain flocks/herds • FYI: other ovine/caprine retroviruses: • Maedi-Visna (ovine progressive pneumonia), caprine arthritis encephalitis

  8. Gross Lesions

  9. Further Diagnostics • PCR • Immunohistochemistry • Electron microscopy Sugar Not Sugar

  10. Treatment • Surgical removal • Can be very bloody! Prepare for transfusion • Many die within 3 months after diagnosis

  11. Sugar • IHC positive on biopsy and aspirated fluid • EM was less rewarding • hard to differentiate from cilia • PCR is pending…

  12. References • De Las Heras M, et al. Pathology of enzootic intranasal tumor in thirty-eight goats. Vet Pathol. 1991;28:474-481. • McKinnon AO, et al. Enzootic nasal adenocarcinoma of sheep in Canada. Can Vet J. 1982;23:88-94. • Martini JC, DF York. Retrovirus-associated neoplasms of the respiratory system of sheep and goats. Vet Clin North Am Food AnimPract. 1997;13:55-70. • Pugh DG. Upper Respiratory Diseases in Sheep and goat medicine. 2002. Elsevier. • Svara T, et al. Enzootic nasal adenocarcinoma of sheep in Slovenia. J Vet Med. 2006;53:26-29. • Yi G, et al. Descriptive study of enzootic nasal adenocarcinoma in goats in southwestern China. Trans Emerg Diseases. 2010;57:197-200.

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