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Methodological Issues in Outcome Research

Methodological Issues in Outcome Research. Effective Healthcare AHRQ 2008 Conference September 7-10, 2008. Purpose. To discuss state of the art analytical approaches to adjust for confounding in observational research within the Effective Health Care Program

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Methodological Issues in Outcome Research

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  1. Methodological Issues in Outcome Research Effective Healthcare AHRQ 2008 Conference September 7-10, 2008

  2. Purpose • To discuss state of the art analytical approaches to adjust for confounding in observational research within the Effective Health Care Program • Measured confounders: Propensity score • Unmeasured confounders: • Sensitivity analysis • Instrumental variables

  3. Panelists • John D. Seeger, PharmD., DrPH. • Senior scientist, Ingenix/i3 Drug Safety • Transparency in the Use of Propensity Score Methods • Sebastian Schneeweiss, M.D., ScD • Department of Medicine, Harvard Medical School • Principal Investigator of Brigham and Women’s Hospital DEcIDE Center • Sensitivity Analysis for Residual Confounding • Alan M. Brookhart, Ph.D. • Brigham and Women’s Hospital, Harvard medical School • Instrumental variable analysis for comparative effectiveness research

  4. Ground Rules • Each panelist will present for ~20-25 minutes • Questions and comments should be made at the end of session. • If you have a question, please come to the microphone if possible. • Please identify the panelist to whom the question is addressed.

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