Cyclosporin Nephrotoxicity. Some of the indications for the use of cyclosporin include the prevention of graft rejection in renal transplant recipients and autoimmune diseases. . How cyclosporin nephrotoxicity is manifested .
Include Diltiazem, Verapamil and Nicardipine
To determine creatinine clearance
CrCl (mL/min): Ucr * Vurine
Scr * T
Clcr(male) = BW *(140-age) / 72*Crserum
Clcr(female) = above equation*0.85
BW (body weight) - Kg
Age - years
Crserum - mg/dL
Note: formula different for men and women because of gender dependent differences in muscle mass.
(Normal muscle mass).
Estimate urinary Cr excretion rate
E(male) = LBW(29.3 – (0.203 * age))
E(female) = LBW(25.1 – (0.175 * age))
Correct E for non reanl Cr excretion in chronic renal failure
E(corrected) = E(1.035 – (0.0337 * Crserum(avg))
Correct E for rising serum Cr
E = E – (4 * LBW * (Crserum1 – Crserum2))/Time
Calc normalised CrCl
CrCl/1.73m2 = (E * 0.12) / (Crserum * BSA)
Clcr = (k * Ht) / Crserum
Clcr in mL/min/1.73m2
Ht- height in cm
K = 0.45 if age < 1 year
K = 0.55 if age 1-12 years.
Clcr(male) = (137-age)*((0.2858*Wt) + (12.1*Ht2))
Clcr(female) = (146-age)*((0.287*Wt) + (9.74*Ht2))
Ht:height in metres
Wt: weight in kg
Age in years.