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BDNF - PowerPoint PPT Presentation


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BDNF. Brain-derived neurotrophic factor (BDNF) is a 25-kDa CNS protein implicated in neuronal cell growth and differentiation. 5-HT and BDNF-regulated intracellular signal tranduction pathways. A model for antidepressant treatment .

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BDNF
  • Brain-derived neurotrophic factor (BDNF) is a 25-kDa CNS protein implicated in neuronal cell growth and differentiation
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BDNF gene in mice has 6 upstream exons and 1 coding sequence 9 different BDNF isoforms produced by alternative splicing

  • Splice variants thought to contain different promoter sequences which respond to temporal, spatial and biochemical cues