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DO NOW: What does LD-50 refer to? Define acute poisoning

SWBAT understand the process of isolating and identifying drugs, toxins and poisons in human tissue. SWBAT compare and contrast test used to identify drugs, toxins and poisons. Objective: . DO NOW: What does LD-50 refer to? Define acute poisoning

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DO NOW: What does LD-50 refer to? Define acute poisoning

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  1. SWBAT understand the process of isolating and identifying drugs, toxins and poisons in human tissue. • SWBAT compare and contrast test used to identify drugs, toxins and poisons. Objective: DO NOW: What does LD-50 refer to? Define acute poisoning How can the white powder test we used yesterday help in a CSI? Write a definition/purpose for white powder testing in your booklet under testing.

  2. Announcements • 1. You can take your books home • 2. Quiz 3 make-ups must be done by today. • 3. I will only be here for 10 min after school • 4. Test on Tuesday Unit 1-5 – one cheat sheet • 5. New style of Exit Ticket

  3. BOOK 1 • Pg 1 – Toxicology • Pg 2 – drugs • Pg 3 – toxins • Pg 4 - poison • Pg 5 – alcohol BOOK 2 pg 1 – testing Pg 4 - collection

  4. Review • What is LD-50? • What is acute poisoning? Example? • What is chronic poisoning? Example? • How do you collect solids? Liquids? Volatile?

  5. White powder test Turn and Talk • Was that white powder test a presumptive or confirmatory test?

  6. Review • LD- 50 is the amount of substance needed to kill _____ the tested population

  7. Ingested Inhaled Intravenous Topically

  8. Where does the drug go directly after it leaves the stomach/lungs? • A. Into the blood stream • B. Into the kidneys • C. Into the mouth • D. To Ms. Hinton house

  9. Metabolites • Kidney  breaks down into chemical components • Called metabolites • Metabolites are what investigators look for when doing a drug test on a human

  10. Collection • Samples used to test for drug, toxins and poisons include: • Blood, urine, lung tissue, brain tissue, heart tissue, skin, bones, hair, and nails.

  11. CFU… • T/F: Nails can be used to determine the presence of drugs, toxins and poisons.

  12. Drugs can be identified in nail clippings 2-4 weeks following ingestion and can be detected up to 8 months after last usage. Fingernails grow approximately 3-5 mm per month, toenails grow at a much slower rate of 1 mm per month which means that drugs can possibly appear in toenail clippings over 1 year after ingestion.

  13. Extract and Isolated • Remove/ Set apart • Hair/ Nails- test keratin • Tissue samples- acid base • Urinalysis- metabolites • Blood-metabolites • Presumptive test done first

  14. How to collect

  15. Pre lab • Gloves • Cleaning agreement • No spills • Do not pick up materials with no lid, go to it • Assign partner… dishwasher, table cleaner

  16. LAB

  17. Exit Ticket • List two way drugs can get into your system • Drugs break down into chemical components called….. • Sing happy birthday to Ms. Hinton (turn up)

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