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Secondary electron emission in proton-Uracil collision: preliminary results. P.Moretto-Capelle D.Bordenave-Montesquieu A.Bordenave-Montesquieu ( A.Rentenier) Future members: A.Lepadellec M.Richard-Viard

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secondary electron emission in proton uracil collision preliminary results
Secondary electron emission in proton-Uracil collision: preliminary results

P.Moretto-Capelle

D.Bordenave-Montesquieu

A.Bordenave-Montesquieu(A.Rentenier)

Future members:

A.Lepadellec

M.Richard-Viard

IRSAMC, LCAR, UMR 5589 CNRS-Univ.P.Sabatier118 rte de Narbonne, 31062 TOULOUSE CEDEX, FRANCE

study of the damages created on bio molecules by ion impact

Energetic ion

e-

Study of the damages created on bio molecules by ion impact

Interaction of ions with matter: possibility of strong energy deposition in a well defined region around the Bragg peak

Treatment of Tumour: Proton/Hadron therapy

Link between ion interaction and DNA damages?

Secondary electron emission

Radiolysis of Water H, HO

Fragmentation, ionization of bases

effects of secondary electrons
Effects of secondary electrons…

Boudaiffa, Science

Tracks:

From GSI

E<20eV

Ionization

Huo et al

Radiation2004

E>20eV

Dissociatif attachment

Initial electron spectrum??

our interest electrons
Our interest…Electrons!

H+ (H0) in the 100keV energy range (Bragg peak)

Spectroscopy and angular distribution (doubly differential cross sections) of secondary electrons emitted after ion-biomolecule interaction

Biomolecule in gaz phase:H2O, Bases of RNA, DNA: Uracil, Cytosine, Thymine…

 Electron spectroscopy correlated with fragmentation

Future: Solvated biomolecule (coll M.and B. Farizon)

Biomolecule on surface (M.Richard-Viard)

experimental apparatus
Experimental apparatus

IonTime of flight spectrometer

Cylindrical electron analyser

High resolution electron spectrometer

‘Total’ electron detector

Oven

Ion beam 1-150keV

*Continuous

*Pulsed 5ns

first experimental results h uracil
First experimental results: H++Uracil

Test of the Jet: Fragmentation

electron spectroscopy h 100kev uracil

H+

e-

35°

Electron spectroscopy: H+(100keV) + Uracil

U

T

H2O

Denifl et al

Chem.Phys.Lett 2003

C

Electron

collision energy dependence
Collision energy dependence

Increase of <electron energy> with collision energy

Corresponding intensity

link between electron emission and fragmentation
Link between electron emission and fragmentation?

Not yet investigated in ion / bio molecule collision… But in H3+ + C60 collision

Partial spectra

Electron spectrum depends of fragmentation pattern

Average energy of the electrons:

Stable ions Evap/fission Multifragmentation

<Ec>=19 eV 24 eV 28 eV

interpretation
Interpretation

Deposited energy (eV)

Intensity (arb.unit)

Electron energy (eV)

Impact parameter (ua)

Small impact parameter: high energy electron AND high energy deposited Large impact parameter: low energy electron AND low energy deposited

Key parameter: impact parameter  Biomolecules???

summary
Summary

Spectroscopy of electrons emitted after H++ biomolecules (DNA, RNA bases) in gas phase

Correlation between electron spectroscopy and fragmentation

For questions about this presentation, please write to

Patrick Moretto-Capelle

pmc@irsamc.ups-tlse.fr

I (PMC) would like to thank sincerely M.Richard-Viard for the presentation of this talk at the conference.