Commissioning and using systematic reviews: a decision-maker’s perspective. Kalipso Chalkidou NICE, UK. Topic Selection. Independent horizon scanning; web-based suggestions; field consultants; regular evidence review by NICE information teams
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Biases… decision-maker’s perspective
(Miners et al, BMJ 2005)
Experiment, observation and mathematics – individually and collectively – have a crucial role to play in providing the evidential basis for modern therapeutics. Hierarchies of evidence should be replaced by accepting – indeed embracing – a diversity of approaches. This is not a plea to abandon RCTs and replace them with observational studies. Rather, it is a plea to investigators to continue to develop and improve their methodologies; to decision makers to avoid adopting entrenched positions about the nature of evidence; and for both to accept that the interpretation of evidence requires judgement.” M Rawlins, 2008 Harveian Oration
*Grade Working Group. CMAJ 2003, BMJ 2004, BMC 2004, BMC 2005
Clinical research told us the amount of psoriasis was what most affected the quality of life.
Patients told us that the location of the flare-up (e.g. face or joints) was more significant.
Topic referred to NICE*
* Published on NICE web site