Poster session n. 2. Abstract # 570: RANKL and RANK Expression in GCTB: an Immunohistochemical Study M Roudier, et al, Amgen Inc. Giant cell tumor of bone (GCTB) results in osteoclast-mediated osteolysis.
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Giant cell tumor of bone (GCTB) results in osteoclast-mediated osteolysis.
RANKL, via its receptor RANK, is essential for osteoclast formation, function and survival.
OPG is a soluble decoy receptor for RANKL and a physiological inhibitor of RANKL function.
We used immunohistochemistry to evaluate RANK, RANKL, and OPG expression in a series of archival GCTB specimens.
MIF (macrophage migration inhibitory factor)
Cytokine involved in many immune responses
implication in angiogenesis, tumor growth, invasion and metastasis
To investigate the expression of MIF and its clinicopathologic significance
Materials and methods
58 osteosarcoma patient samples