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Canonical Pathway Analysis of Cholesterol Metabolism: Gene Expression Changes

This study by Kleemann et al. (2007) highlights the canonical pathway analysis of cholesterol metabolism, presenting the top-scored map from enrichment analysis. Gene expression alterations are depicted as thermometer-like figures, indicating down-regulation by high cholesterol (HC) and low cholesterol (LC) diets through colored representations. The pivotal step in cholesterol synthesis, the conversion of hydroxymethylglutaryl-CoA to mevalonate, catalyzed by HMG-CoA reductase, is emphasized. Additionally, a global analysis of gene expression changes in relation to over 500 human diseases is provided.

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Canonical Pathway Analysis of Cholesterol Metabolism: Gene Expression Changes

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  1. Kleemann et al., 2007, additional data file 4 Additional data file 4:A, Canonical pathway analysis of cholesterol metabolism, which is the top scored map of the enrichment analysis using canonical pathways. Gene expression changes are visualized on the map as thermometer-like figures. Down-regulation of the genes (blue color) by HC and LC is indicated with (1) and (2), respectively. The rate-limiting step in the pathway to cholesterol synthesis (and a major site of regulation) is the conversion of hydroxymethylglutaryl-CoA to mevalonate, a reaction catalyzed by HMG-CoA reductase (HMDH; blue circle). Metabolites are depicted as . B, Global analysis of changes in gene expression in LC and HC using disease categories based on over 500 human diseases with gene content annotated in MetaCore software (GeneGO). Top twenty diseases are shown for LC and HC including their P-value. A

  2. Kleemann et al., 2007 B LC HC

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