Afzelin

1. Afzelin: Overview, Structure, Properties and Formulas Afzelin can be portrayed as a glycosyloxyflavone. It is made from kaempferol and an alpha-L–rhamnosyl buildup situated at position 3. It is done through a glycosidic connecting. It fills in as an antibacterial, antibacterial, and calming plant metabolite. It is a glycosyloxyflavone. It comes from kaempferol. It is a form amino of an afzelin (1-). There are numerous compound stores from where you can buy chemicals online. You can visit the most confided in ones and can arrange your necessary one for research and for other reason. Purchase synthetic compounds on the web and afzelin from various merchants. These synthetic compounds can likewise be looked on changed internet-based stores. IUPAC Name 5,7-dihydroxy-2-(4-hydroxyphenyl)-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan- 2-yl]oxychromen-4-one MeSH Entry Terms Afzelin deacyl-SL0101 kaempferol-3-O-alpha-L-rhamnoside kaempferol-3-rhamnoside •Molecular Formula C21H20O10 •Average mass 432.378 Da •Monoisotopic mass 432.105652 Da Afzelin 482-39-3 kaempferol-3-rhamnoside Kaempferin Kaempferol 3-rhamnoside •Synonyms

2. Properties Property Value Property Name Reference Computed by PubChem 2.1 (PubChem release 2021.05.07) Molecular Weight 432.4 Computed by XLogP3 3.0 (PubChem release 2021.05.07) XLogP3-AA 1.2 Hydrogen Count Bond Donor Computed by Cactvs 3.4.8.18 (PubChem release 2021.05.07) 6 Hydrogen Bond Acceptor Count Computed by Cactvs 3.4.8.18 (PubChem release 2021.05.07) 10 Computed by Cactvs 3.4.8.18 (PubChem release 2021.05.07) Rotatable Bond Count 3

3. Computed by PubChem 2.1 (PubChem release 2021.05.07) Exact Mass 432.10564683 Computed by PubChem 2.1 (PubChem release 2021.05.07) Monoisotopic Mass 432.10564683 Topological Polar Surface Area Computed by Cactvs 3.4.8.18 (PubChem release 2021.05.07) 166 Ų Heavy Atom Count 31 Computed by PubChem Formal Charge 0 Computed by PubChem Computed by Cactvs 3.4.8.18 (PubChem release 2021.05.07) Complexity 702 Isotope Atom Count 0 Computed by PubChem Defined Atom Stereocenter Count 5 Computed by PubChem Undefined Stereocenter Count Atom 0 Computed by PubChem Defined Bond Stereocenter Count 0 Computed by PubChem Undefined Stereocenter Count Bond 0 Computed by PubChem Covalently-Bonded Count Unit 1 Computed by PubChem Compound Canonicalized Is Computed 2021.05.07) by PubChem (release Yes General description Afzelin is a natural product made from plant material. The Ficus palate is the most crucial source of afzelin. Nymphaea or atom is the primary source. Application Afzelin has antibacterial, DNA-protective, and antioxidant properties. Afzelin can be detected in HPLC (high-performance liquid chromatography) analysis Comarum PalustreL. Extract.

4. Antibacterial, DNA-protective, and antioxidant. Biochem/Physiol Actions Afzelin has been shown to have antibacterial, anti-inflammatory, and anti-tumor activity. Therefore, Afzelin could be used to treat P.aeruginosa-related disorders. Afzelin can also be used to promote apoptosis and inhibit breast cancer cell proliferation. In addition, it has anti-asthmatic activity in a mouse model. Afzelin, kaempferol 3O-rhamnoside and kaempferol 3O-rhamnoside both belong to the flavonol sugar group. Afzelin can be found in 56 plants. It has been found in 56 plants, making it easily accessible. 15 It was demonstrated that afzelin inhibits Rac1–GTPase activation and reduced focal adhesionkinase (FAK), but the target proteins have yet to be identified. Results GalN/LPS treated mice with Afzelin had a greater survival rate and lower serum levels of pro- inflammatory and cytokines. Afzelin decreased mitochondrial swelling in GalN/LPS mice and increased mitochondrial glutamate dehydrogenase activity. Afzelin promoted mitochondrial biogenesis. This was evident by increased PPAR-g activator 1a, nuclear Respir factor 1, and mitochondrial transcript factor A. Afzelin also reduced the levels of mitophagy related proteins, parkin, and PTEN-induced kinase 1. GalN/LPS increased the levels of dynamin-related protein one and dynamin-related prot1, respectively, but these effects were reduced by afzelin. Afzelin is a natural flavonol glycoside flavonol product that's derived from Kaempferol. It contains four hydroxy group positions 3, 5, 7, and 4 on the flavone. The afzelin is created by forming a glycosidic bond between the 3-O-atom of Kaempferol and a-L–rhamnose. This results in the presence of 3 phenol and five stereogenic centers. Afzelin was recently evaluated for its biological properties. It has been shown to have antibacterial activity and high aldose reductase inhibitory activities. In conclusion, the central administration of afzelin ameliorates scopolamine-induced cognitive impairment in the brain. These effects of afzelin might be related to restored cholinergic dysfunction, enhanced LTP, and an increase of BDNF/CREB signaling. Conclusions Our findings showed that afzelin protects liver injury from GalN/LPS by stimulating mitochondrial biogenesis, suppressing excess mitophagy, and balancing the mitochondrial dynamics. Afzelin decreases mitochondrial damage, improves mitochondrial biogenesis, reduces mitophagy-related proteins, parkin, as well as the levels of PTEN-induced putative kinase 1. In addition, Afzelin reduces the mortality rate and serum levels of pro-inflammatory and cytokines in D.- galactosamine/LPS-treated mice.