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VSEL - PowerPoint PPT Presentation


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A. bGH- WT (6M). bGH- TG (6 M). bGH- WT (1Y). bGH- TG (1 Y). MNC. MNC. MNC. MNC. MNC. MNC. MNC. MNC. MNC. MNC. HSC. VSEL. HSC. HSC. HSC. HSC. VSEL. VSEL. VSEL. VSEL. VSEL. HSC. VSEL. VSEL. VSEL. VSEL. HSC. HSC. HSC. HSC. BstUI. BstUI. H19. H19. -. -. -. -.

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Presentation Transcript
slide1

A

bGH-WT (6M)

bGH-TG (6 M)

bGH-WT (1Y)

bGH-TG (1 Y)

MNC

MNC

MNC

MNC

MNC

MNC

MNC

MNC

MNC

MNC

HSC

VSEL

HSC

HSC

HSC

HSC

VSEL

VSEL

VSEL

VSEL

VSEL

HSC

VSEL

VSEL

VSEL

VSEL

HSC

HSC

HSC

HSC

BstUI

BstUI

H19

H19

-

-

-

-

-

-

+

+

+

+

+

+

-

-

-

-

-

-

+

+

+

+

+

+

-

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-

-

-

-

+

+

+

+

+

+

-

-

-

-

-

-

+

+

+

+

+

+

-

-

-

-

-

-

+

+

+

+

+

+

-

-

-

-

-

-

+

+

+

+

+

+

Rasgrf1

Rasgrf1

*

*

B

Prop1df/+ (20 M)

Prop1df/df (20 M)

GHR+/- (20 M)

GHR-/- (20 M)

MNC

MNC

HSC

VSEL

VSEL

HSC

BstUI

BstUI

H19

H19

Igf2-H19-DMR

Igf2-H19-DMR

C

Prop1df/df(2 M) + GH

Prop1df/df(2 M) + Saline

Prop1df/df (8 M) + GH

Prop1df/df (8 M) + Saline

BstUI

BstUI

H19

H19

Supplementary Figure 1