Klinefelter s syndrome
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Klinefelter’s Syndrome. AP Biology 2 3 rd period Michelle Xu & Alice Thai. What is Klinefelter’s Syndrome?. Klinefelter's syndrome is a genetic disorder that only affects males.

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Klinefelter s syndrome

Klinefelter’s Syndrome

AP Biology 2

3rd period

Michelle Xu &

Alice Thai

What is klinefelter s syndrome
What is Klinefelter’s Syndrome?

  • Klinefelter's syndrome is a genetic disorder that only affects males.

  • It occurs when a boy is born with one or more extra X chromosomes, which causes a boy to produce less testosterone than a normal boy. .

  • Due to having an extra X chromosome, the male may possibly have some physical traits unusual for males.

What is klinefelter s syndrome1
What is Klinefelter’s Syndrome?

  • Instead of an XY sex chromosome pattern that most males have, these males have an XXY pattern.

  • Some people with Kleinfelter’s consider themselves to be transgender, intersexed, or transsexual, due to having a more feminine appearance and/or feminine emotions.

Other names for klinefelter s
Other Names for Klinefelter’s:

  • 47, XXY

  • XXY Syndrome

  • XXY Trisomy

  • Or 3+X Chromosomes with Y

Frequency of Klinefelter’s:

  • Approximately 1 in 500 to 1,000.

How do you get klinefelter s syndrome
How do you get Klinefelter’s Syndrome?

  • An extra X chromosome most often occurs when the genetic material in the eggs or the sperm splits unevenly.

  • It’s a random event during the formation of reproductive cells

  • An error in cell division called nondisjunction results in a reproductive cell with an abnormal number of chromosomes.

  • It’s diagnosed in adulthood by using a karyotype.

Symptoms of klinefelter s syndrome
Symptoms of Klinefelter’s Syndrome

Physical Symptoms:

  • Long legs

  • Wide hips

  • Enlarged breasts

  • Sparse body hair

  • Small testicles

  • Less muscular

  • Weaker bones

Symptoms of klinefelter s syndrome1
Symptoms of Klinefelter’s Syndrome

Language Symptoms:

  • Learn to talk late

  • Trouble expressing thoughts and needs

  • Problems reading

  • Trouble processing what they hear

    Other Symptoms:

  • Normal sex lives, but cannot father children

  • Produce much less testosterone

Treatment of klinefelter s syndrome
Treatment of Klinefelter’s Syndrome

  • Males with Klinefelter’s Syndrome can be given testosterone therapy.

  • If given around the age of puberty, it can help a boy have normal body development.

  • A infertility specialist may be able to help a male with Klinefelter’s syndrome to get a woman pregnant.

History of klinefelter s syndrome
History of Klinefelter’s Syndrome

  • In 1942, Klinefelter’s was discovered by Dr. Harry Klinefelter, along with other doctors at General Hospital in Boston.

  • Doctors reported a group of males with “enlarged breasts, sparse facial and body hair, small testes, and inability to produce sperm.”

  • By the late 1950’s, researches discovered that these men had an extra sex chromosome thus having the pattern XXY.

Lifestyle with klinefelter s syndrome
Lifestyle with Klinefelter’s Syndrome

As a Baby, Child, and Teen:

  • May sit up, crawl, and walk later than other infants.

  • Tend to be taller and have less muscle control than other boys.

  • May have language problems

  • Tend to be quiet and undemanding.

  • Entering puberty, these males don’t make as much testosterone.

Lifestyle with klinefelter s syndrome1
Lifestyle with Klinefelter’s Syndrome

As an Adult:

  • Look similar to normal males, but are often taller.

  • Likely to have health problems such as breast cancer, vein diseases, tooth decay, and autoimmune disorders.

  • Cannot father children due to infertility.

  • May have a harder time doing work that involves reading and writing.

  • Normal social life with friends and family.

Caroline cossey xxxy
Caroline Cossey (XXXY)

  • Cossey was raised as a boy, but changed lifestyle to live as a girl.

  • She became a famous model.

  • She underwent sex-reassignment surgery.

  • Cossey was a James Bond girl in the movie “For Your Eyes Only.”

Lili elbe
Lili Elbe

  • Elbe allegedly had Klinefelter’s.

  • She was one of the first identifiable recipients of male to female sex reassignment surgery.

  • Elbe was a fashion model.

  • She was transsexual and underwent experimental surgeries, her first surgery was orchiectomy (removal of testicles).

  • Elbe was written about in David Ebershoff’s best seller, The Danish Girl.

Works cited
Works Cited

  • http://men.webmd.com/tc/klinefelter-syndrome-topic-overview

  • http://www.livestrong.com/article/30547-testosterone-treatment-klinefelters-syndrome-work/

  • http://www.nichd.nih.gov/health/topics/klinefelter_syndrome.cfm

  • http://ghr.nlm.nih.gov/condition/klinefelter-syndrome

  • http://www.nlm.nih.gov/medlineplus/ency/article/000382.htm

  • http://ghr.nlm.nih.gov/condition/klinefelter-syndrome

  • http://learn.genetics.utah.edu/content/disorders/whataregd/klinefelter/

  • http://genetics.emedtv.com/klinefelter-syndrome/history-of-klinefelter-syndrome.html

  • http://www.hawaii.edu/PCSS/biblio/articles/2000to2004/2004-ais-and-klinefelters.html

  • http://www.imdb.com/name/nm0876302/bio

  • http://sexual-communication.wikispaces.com/Lili+Elbe