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Literature Sources in Pharmacovigilance

Literature Sources in Pharmacovigilance. Sten Olsson WHO-Uppsala Monitoring Centre Sweden. Original journals. Positive Fast Comprehensive information Negative Expensive Low coverage JAMA Therapie New Engl J of Med Brit Med Journal The Lancet. http://bmj.com/.

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Literature Sources in Pharmacovigilance

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  1. Literature Sources in Pharmacovigilance Sten Olsson WHO-Uppsala Monitoring Centre Sweden

  2. Original journals • Positive • Fast • Comprehensive information • Negative • Expensive • Low coverage • JAMA • Therapie • New Engl J of Med • Brit Med Journal • The Lancet

  3. http://bmj.com/

  4. Journals of special interest • Pharmacoepidemiology & Drug Safety • Drug Safety • Risk & Safety in Medicine

  5. Bibliographic titles review • Positive Fast High coverage • Negative Minimal detail Current Contents

  6. Secondary review journals • Positive - Quite fast - Some detail - High coverage • Negative - Lack of detail - Difficult to search systematically - (Cost) • Reactions Weekly

  7. Positive - Assessment of significance - Easy access Negative - Lack of detail - Not completely up-to-date Meyler's Side Effects of Drugs Side Effects of Drugs Annual Adverse Drug Reaction Bulletin Prescrire Expert Opinion on Drug Safety Expert annotated review

  8. Reference books • Martindale – the extra Pharmacopoea • Meyler’s Side Effects of Drugs • Pharmacovigilance from A-Z • Dictionary of Pharmacovigilance

  9. Textbooks • Drug induced diseases • Textbook of Adverse Drug Reactions (Davies, 1998) • Avery's Drug Treatment (Speight, 1997) • Drug Benefits and Risks (van Boxtel, Santoso, Edwards, 2002) • Adverse Drug Reactions (Lee, 2001)

  10. Methodology • Pharmacovigilance (Mann, Andrews, 2002) • Pharmacoepidemiology (Strom, 2000) • Stephens’ Detection of New Adverse Drug Reactions (Talbot, Waller, 2004) • Adverse Drug Reactions: A practical guide to Diagnosis and Management (Bénichou, 1996)

  11. Adverse Drug Interactions(Griffin, D'Arcy, 1997) Drugs in Pregnancy and Lactation (Briggs, Freeman,Yaffe, 1998) Drug-induced Ocular Side Effects (Fraunfelder, 2002) Adverse Effects of Herbal Drugs(De Smet et al 1992) Adverse Events Associated with childhood vaccines (Instit of Med, 1994) Responsibility for Drug-induced Injury (Dukes, Mildred, Swartz, 1998) Safety of Anaesthetic Drugs (Naguib, 1998) To Heal And Harm: An economic view on drug safety (Silcock and Pritchard, 2003) Reference booksAddressing specific problem areas

  12. References online • Micromedex • Includes Martindale, PDR, Alternative Medicines and Index Nominum • Merck Manual • Includes: The Merck Manual of Diagnosis and Therapy • SAM=Scientific American Medicine

  13. Computerized literature screening (1/2) • Positive • High coverage • High specificity of search • Negative • Requires equipment & skill • Lack of detail

  14. Computerized literature screening (2/2) • Medline • Pubmed is using the MeSH (Medical Subject Headings) terminology. • EMBASE • Current Contents on CD • Reactions Weekly on-line

  15. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed

  16. WHO Publications • WHO Pharmaceuticals Newsletter • WHO Drug Information • Dialogue in Pharmacovigilance • Viewpoint 1 & 2 • Expecting the Worst • Uppsala Reports

  17. NATIONAL ADR BULLETINS • Presciber Update, New Zealand • Australian Adverse Reactions Bulletin • Signals in Adverse Drug Reactions Monitoring, The Philippines • Butlletí Groc and many other regional bulletins, Spain • Information från Läkemedelsverket, Sweden • Drug Information Bulletin, Tanzania

  18. NATIONAL ADR BULLETINS (2) • Berita Ubat-Ubatan, Malaysia • Folia Pharmacoterapeutica, Belgium • Canadian Adverse Drug Reaction Newsletter • TABU, Finland • Drug Safety Newsletter, Ireland • Information on Adverse Reactions to Drugs, Japan • Adverse Drug Reaction News, Singapore

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